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In This Issue
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Cell
Cancer cells are now revealing their metabolic secrets with a combination of biochemical approaches and omic-level analyses. This issue's Select highlights articles that begin to clarify how cells....
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Ruth I. Tennen, Eriko Michishita-Kioi, Katrin F. Chua. Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now sh....
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Ajit Lalvani, Marcel A. Behr, Saranya Sridhar. Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a cr....
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Kevin J. Tracey. Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a speci....
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Daniel R. Foltz, P. Todd Stukenberg. The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino....
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Li Qiang, Domenico Accili. Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate....
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Gregg L. Semenza. Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional acti....
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Janet E. Dancey, Philippe L. Bedard, Nicole Onetto, Thomas J. Hudson. Personalized cancer medicine is based on increased knowledge of the cancer mutation repertoire and availability of agents that target altered genes or pathways. Given advances in cancer genetics, ....
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Cell
Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L. Brown, Myung K. Kim, Michael A. Beaven, Alex B. Burgin, Vincent Manganiello, Jay H. Chung. Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplemen....
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Cell
David M. Tobin, Francisco J. Roca, Sungwhan F. Oh, Ross McFarland, Thad W. Vickery, John P. Ray, Dennis C. Ko, Yuxia Zou, Nguyen D. Bang, Tran T.H. Chau, Jay C. Vary, Thomas R. Hawn, Sarah J. Dunstan, Jeremy J. Farrar, Guy E. Thwaites, Mary-Claire King, Charles N. Serhan, Lalita Ramakrishnan. Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium....
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Cell
Yasunobu Arima, Masaya Harada, Daisuke Kamimura, Jin-Haeng Park, Fuminori Kawano, Fiona E. Yull, Tadafumi Kawamoto, Yoichiro Iwakura, Ulrich A.K. Betz, Gabriel Márquez, Timothy S. Blackwell, Yoshinobu Ohira, Toshio Hirano, Masaaki Murakami. Although it is believed that neural activation can affect immune responses, very little is known about the neuroimmune interactions involved, especially the regulators of immune traffic across the....
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Guillaume Junion, Mikhail Spivakov, Charles Girardot, Martina Braun, E. Hilary Gustafson, Ewan Birney, Eileen E.M. Furlong. Cell fate decisions are driven through the integration of inductive signals and tissue-specific transcription factors (TFs), although the details on how this information converges in cis re....
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Tatsuya Nishino, Kozo Takeuchi, Karen E. Gascoigne, Aussie Suzuki, Tetsuya Hori, Takuji Oyama, Kosuke Morikawa, Iain M. Cheeseman, Tatsuo Fukagawa. The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specif....
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Liedewij Laan, Nenad Pavin, Julien Husson, Guillaume Romet-Lemonne, Martijn van Duijn, Magdalena Preciado López, Ronald D. Vale, Frank Jülicher, Samara L. Reck-Peterson, Marileen Dogterom. Dynein at the cortex contributes to microtubule-based positioning processes such as spindle positioning during embryonic cell division and centrosome positioning during fibroblast migration. To in....
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Xinchao Yu, Marianna Breitman, Jonathan Goldberg. Budding of COPI-coated vesicles from Golgi membranes requires an Arf family G protein and the coatomer complex recruited from cytosol. Arf is also required with coatomer-related clathrin adaptor c....
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Eric Lau, Harriet Kluger, Tal Varsano, KiYoung Lee, Immo Scheffler, David L. Rimm, Trey Ideker, Ze'ev A. Ronai. The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determi....
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Paul A. Dutchak, Takeshi Katafuchi, Angie L. Bookout, Jang Hyun Choi, Ruth T. Yu, David J. Mangelsdorf, Steven A. Kliewer. Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine fa....
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Cell
Dario Bonanomi, Onanong Chivatakarn, Ge Bai, Houari Abdesselem, Karen Lettieri, Till Marquardt, Brian A. Pierchala, Samuel L. Pfaff. Growing axons encounter multiple guidance cues, but it is unclear how separate signals are resolved and integrated into coherent instructions for growth cone navigation. We report that glycosylpho....
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Hidehiko K. Inagaki, Shlomo Ben-Tabou de-Leon, Allan M. Wong, Smitha Jagadish, Hiroshi Ishimoto, Gilad Barnea, Toshihiro Kitamoto, Richard Axel, David J. Anderson. Behavior cannot be predicted from a “connectome” because the brain contains a chemical “map” of neuromodulation superimposed upon its synaptic connectivity map. Neuromodulation changes how neural ....
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Xiaohong Xu, Jennifer K. Coats, Cindy F. Yang, Amy Wang, Osama M. Ahmed, Maricruz Alvarado, Tetsuro Izumi, Nirao M. Shah. Sex hormones such as estrogen and testosterone are essential for sexually dimorphic behaviors in vertebrates. However, the hormone-activated molecular mechanisms that control the development and f....
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Shalev Itzkovitz, Irene C. Blat, Tyler Jacks, Hans Clevers, Alexander van Oudenaarden. Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigat....
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Cell
Michael J. Emanuele, Andrew E.H. Elia, Qikai Xu, Claudio R. Thoma, Lior Izhar, Yumei Leng, Ailan Guo, Yi-Ning Chen, John Rush, Paul Wei-Che Hsu, Hsueh-Chi Sherry Yen, Stephen J. Elledge.
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Takashi Kadowaki, Kohjiro Ueki, Toshimasa Yamauchi, Naoto Kubota.
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Wenyu Luo, Amita Sehgal. Although molecular components of the circadian clock are known, mechanisms that transmit signals from the clock and produce rhythmic behavior are poorly understood. We find that the microRNA mi....
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Amitabha Majumdar, Wanda Colón Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, Mohammed “Repon” Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Fengli Guo, Jay Unruh, Brian Slaughter, Kausik Si. A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days. Previously, we ....
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In This Issue
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2011 was a blockbuster year for the stem cell field. Researchers made great progress in growing complex organs in vitro and producing a variety of cell types on demand. But in the last few months,....
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Cell
Emilie, Elena, Robert, Karen, Lara, Faby, Michaeleen, Niki, C. Kara, L. Kara, Rosy.
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Colin Macilwain. Biomedical research budgets are frozen or falling in developed countries. Can expansion in developing nations continue as economic contagion spreads?
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Francis Ka-Ming Chan, Eric H. Baehrecke. Programmed necrosis has long been recognized as a crucial component of animal development; however, the signaling pathway beyond the protein kinases RIP1 and RIP3 remains largely unknown. Sun et a....
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David A. Tuveson, John P. Neoptolemos. Although metastasis is a major cause of morbidity and mortality in patients with pancreatic cancer, the requisite events are currently unknown. In this issue of Cell, Haeno et al. and Rhim ....
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Sayako Katada, Axel Imhof, Paolo Sassone-Corsi. Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent stu....
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Christopher A. Maher, Richard K. Wilson. The unprecedented resolution of high-throughput genomics has enabled the recent discovery of a phenomenon by which specific regions of the genome are shattered and then stitched together via a sin....
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Kai Kretzschmar, Fiona M. Watt. Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19th century, lineage tracing is n....
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Thomas A. Rando, Howard Y. Chang. The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental ....
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Cell
Tobias Rausch, David T.W. Jones, Marc Zapatka, Adrian M. Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A. Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E. Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M. Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G. Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J. Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D. Taylor, Peter Lichter, Stefan M. Pfister, Jan O. Korbel. Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one....
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Zhaoyu Li, Geetu Tuteja, Jonathan Schug, Klaus H. Kaestner. Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with significantly higher incidence in males, an effect that is dependent on sex hormones. The molecular mechanisms....
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Cell
Guoliang Li, Xiaoan Ruan, Raymond K. Auerbach, Kuljeet Singh Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus Hendriyan Mulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, Steve Landt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang, Carrie Davis, Katherine I. Fisher-Aylor, Ali Mortazavi, Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, Yijun Ruan. Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), w....
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Simon R.V. Knott, Jared M. Peace, A. Zachary Ostrow, Yan Gan, Alexandra E. Rex, Christopher J. Viggiani, Simon Tavaré, Oscar M. Aparicio. The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timin....
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Pierre Rocheteau, Barbara Gayraud-Morel, Irene Siegl-Cachedenier, Maria A. Blasco, Shahragim Tajbakhsh. Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly defined heterogeneous population. Using transgenic Tg:Pax7-nGFP mice, we show that Pax7-nGFP
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Clarissa J. Nobile, Emily P. Fox, Jeniel E. Nett, Trevor R. Sorrells, Quinn M. Mitrovich, Aaron D. Hernday, Brian B. Tuch, David R. Andes, Alexander D. Johnson. A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, we....
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Cell
Wael M. Rabeh, Florian Bossard, Haijin Xu, Tsukasa Okiyoneda, Miklos Bagdany, Cory M. Mulvihill, Kai Du, Salvatore di Bernardo, Yuhong Liu, Lars Konermann, Ariel Roldan, Gergely L. Lukacs. The folding and misfolding mechanism of multidomain proteins remains poorly understood. Although thermodynamic instability of the first nucleotide-binding domain (NBD1) of ΔF508 CFTR (cystic fibro....
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Cell
Juan L. Mendoza, André Schmidt, Qin Li, Emmanuel Nuvaga, Tyler Barrett, Robert J. Bridges, Andrew P. Feranchak, Chad A. Brautigam, Philip J. Thomas. Misfolding of ΔF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR) underlies pathology in most CF patients. F508 resides in the first nucleotide-binding domain (NBD1) of CFTR near....
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Andrew R. Houk, Alexandra Jilkine, Cecile O. Mejean, Rostislav Boltyanskiy, Eric R. Dufresne, Sigurd B. Angenent, Steven J. Altschuler, Lani F. Wu, Orion D. Weiner. Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional ....
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Cell
Koshi Kunimoto, Yuji Yamazaki, Tomoki Nishida, Kyosuke Shinohara, Hiroaki Ishikawa, Toshiaki Hasegawa, Takeshi Okanoue, Hiroshi Hamada, Tetsuo Noda, Atsushi Tamura, Shoichiro Tsukita, Sachiko Tsukita. Coordinated beating of cilia in the trachea generates a directional flow of mucus required to clear the airways. Each cilium originates from a barrel-shaped basal body, from the side of which prot....
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Cell
Souvik Bhattacharjee, Robert V. Stahelin, Kaye D. Speicher, David W. Speicher, Kasturi Haldar. Hundreds of effector proteins of the human malaria parasite Plasmodium falciparum constitute a “secretome” carrying a host-targeting (HT) signal, which predicts their export from the intrac....
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Cell
Liming Sun, Huayi Wang, Zhigao Wang, Sudan He, She Chen, Daohong Liao, Lai Wang, Jiacong Yan, Weilong Liu, Xiaoguang Lei, Xiaodong Wang. The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiolog....
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Cell
Zhigao Wang, Hui Jiang, She Chen, Fenghe Du, Xiaodong Wang. The programmed necrosis induced by TNF-α requires the activities of the receptor-interacting serine-threonine kinases RIP1 and RIP3 and their interaction with the mixed lineage kinase domain-like ....
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Cell
William A. Freed-Pastor, Hideaki Mizuno, Xi Zhao, Anita Langerød, Sung-Hwan Moon, Ruth Rodriguez-Barrueco, Anthony Barsotti, Agustin Chicas, Wencheng Li, Alla Polotskaia, Mina J. Bissell, Timothy F. Osborne, Bin Tian, Scott W. Lowe, Jose M. Silva, Anne-Lise Børresen-Dale, Arnold J. Levine, Jill Bargonetti, Carol Prives. p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast ....
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Cell
Nikolaos Balaskas, Ana Ribeiro, Jasmina Panovska, Eric Dessaud, Noriaki Sasai, Karen M. Page, James Briscoe, Vanessa Ribes. Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Son....
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Cell
Yichang Jia, John C. Mu, Susan L. Ackerman. Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their function in the regulation of alternative splicing or of the biological con....
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Cell
Tingting Cui-Wang, Cyril Hanus, Tao Cui, Thomas Helton, Jennifer Bourne, Deborah Watson, Kristen M. Harris, Michael D. Ehlers. Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER) for variable periods that are typically rate limiting for plasma membrane delivery. In neurons, the ER exten....
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Cell
Wei-Chung Chiang, Tsui-Ting Ching, Hee Chul Lee, Carol Mousigian, Ao-Lin Hsu. Extended longevity is often correlated with increased resistance against various stressors. Insulin/IGF-1-like signaling (IIS) is known to have a conserved role in aging and cellular mechanisms ag....
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Cell
Andrew D. Rhim, Emily T. Mirek, Nicole M. Aiello, Anirban Maitra, Jennifer M. Bailey, Florencia McAllister, Maximilian Reichert, Gregory L. Beatty, Anil K. Rustgi, Robert H. Vonderheide, Steven D. Leach, Ben Z. Stanger. Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitiv....
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Cell
Hiroshi Haeno, Mithat Gonen, Meghan B. Davis, Joseph M. Herman, Christine A. Iacobuzio-Donahue, Franziska Michor. Pancreatic cancer is a leading cause of cancer-related death, largely due to metastatic dissemination. We investigated pancreatic cancer progression by utilizing a mathematical framework of metast....
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Cell
Sebastian Guettler, Jose LaRose, Evangelia Petsalaki, Gerald Gish, Andy Scotter, Tony Pawson, Robert Rottapel, Frank Sicheri.
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Cell
Wouter H. Moolenaar, Timothy Hla.
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Cell
Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, Giacomo Cavalli. Chromosomes are the physical realization of genetic information and thus form the basis for its readout and propagation. Here we present a high-resolution chromosomal contact map derived from a mo....
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Cell
Dominic Schmidt, Petra C. Schwalie, Michael D. Wilson, Benoit Ballester, Ângela Gonçalves, Claudia Kutter, Gordon D. Brown, Aileen Marshall, Paul Flicek, Duncan T. Odom. CTCF-binding locations represent regulatory sequences that are highly constrained over the course of evolution. To gain insight into how these DNA elements are conserved and spread through the gen....
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Cell
Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga, Kishore Kumar Bhakoo, Senthil Raja Jayapal, Massimo Nichane, Qiang Yu, Dokeu A. Ahmed, Christie Tan, Wong Poo Sing, John Tam, Agasthian Thirugananam, Monireh Soroush Noghabi, Yin Huei Pang, Haw Siang Ang, Paul Robson, Philipp Kaldis, Ross Andrew Soo, Sanjay Swarup, Elaine Hsuen Lim, Bing Lim. Identification of the factors critical to the tumor-initiating cell (TIC) state may open new avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is criti....
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Cell
Masahito Tachibana, Michelle Sparman, Cathy Ramsey, Hong Ma, Hyo-Sang Lee, Maria Cecilia T. Penedo, Shoukhrat Mitalipov. Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the....
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Alan Trounson, Uta Grieshammer. In this issue, Tachibana et al. report the generation of the first chimeras from a nonhuman primate, the rhesus monkey. Unlike mice, rhesus chimeras fail to form when embryonic stem cells are inje....
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Cell
Einat Segev, Yoav Smith, Sigal Ben-Yehuda. Upon starvation, the bacterium Bacillus subtilis enters the process of sporulation, lasting several hours and culminating in formation of a spore, the most resilient cell type known. We sho....
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Cell
In This Issue
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Cell
In response to cold, the body stimulates brown fat to produce heat. This issue's Select explores recent insights into the molecular and cellular processes that will keep you warm this winter and t....
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Cell
Ignacio Rubio-Somoza, Detlef Weigel, José-Manuel Franco-Zorilla, Juan Antonio García, Javier Paz-Ares.
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Cell
Aseem Z. Ansari, Marsha Rich Rosner, Julius Adler.
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Liam J. Drew, Rene Hen. Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior ....
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Cell
Vivian Bellofatto, Jeffrey Wilusz. The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes ar....
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Cell
Mia T. Levine, Harmit S. Malik. Piwi-interacting RNAs (piRNAs) help defend host genomes against germline transposons. In this issue of Cell, Khurana et al. show how alterations in the piRNA-encoding loci within a single g....
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Cell
Claudia Z. Han, Kodi S. Ravichandran. Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phago....
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Cell
Feng Zhang, Johannes Vierock, Ofer Yizhar, Lief E. Fenno, Satoshi Tsunoda, Arash Kianianmomeni, Matthias Prigge, Andre Berndt, John Cushman, Jürgen Polle, Jon Magnuson, Peter Hegemann, Karl Deisseroth. The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparallele....
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Cell
Almog Bregman, Moran Avraham-Kelbert, Oren Barkai, Lea Duek, Adi Guterman, Mordechai Choder. Promoters are DNA elements that enable transcription and its regulation by trans-acting factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the mRNA leaves....
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Cell
Tatjana Trcek, Daniel R. Larson, Alberto Moldón, Charles C. Query, Robert H. Singer. Messenger RNA decay measurements are typically performed on a population of cells. However, this approach cannot reveal sufficient complexity to provide information on mechanisms that may regulate....
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Cell
Ozlem Yildirim, Ruowang Li, Jui-Hung Hung, Poshen B. Chen, Xianjun Dong, Ly-Sha Ee, Zhiping Weng, Oliver J. Rando, Thomas G. Fazzio. Numerous chromatin regulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been studied in detail. Here, we examine the roles of several chromatin regulato....
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Cell
Qiaoran Xi, Zhanxin Wang, Alexia-Ileana Zaromytidou, Xiang H.-F. Zhang, Lai-Fong Chow-Tsang, Jing X. Liu, Hyesoo Kim, Afsar Barlas, Katia Manova-Todorova, Vesa Kaartinen, Lorenz Studer, Willie Mark, Dinshaw J. Patel, Joan Massagué. Specific chromatin marks keep master regulators of differentiation silent yet poised for activation by extracellular signals. We report that nodal TGF-β signals use the poised histone mark H3K9me3....
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Cell
Igor Ulitsky, Alena Shkumatava, Calvin H. Jan, Hazel Sive, David P. Bartel. Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-....
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Cell
Jaspreet S. Khurana, Jie Wang, Jia Xu, Birgit S. Koppetsch, Travis C. Thomson, Anetta Nowosielska, Chengjian Li, Phillip D. Zamore, Zhiping Weng, William E. Theurkauf. Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasi....
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Cell
Kimberly A. Reynolds, Richard N. McLaughlin, Rama Ranganathan. Recent work indicates a general architecture for proteins in which sparse networks of physically contiguous and coevolving amino acids underlie basic aspects of structure and function. These netwo....
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Cell
Sichen Shao, Ramanujan S. Hegde. Metazoans secrete an extensive array of small proteins essential for intercellular communication, defense, and physiologic regulation. Their synthesis takes mere seconds, leaving minimal time for ....
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Cell
Bama Charan Mondal, Tina Mukherjee, Lolitika Mandal, Cory J. Evans, Sergey A. Sinenko, Julian A. Martinez-Agosto, Utpal Banerjee. Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In the Drosophila hematopoietic organ, niche-derived Hedge....
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Cell
Takatoshi Iijima, Karen Wu, Harald Witte, Yoko Hanno-Iijima, Timo Glatter, Stéphane Richard, Peter Scheiffele. The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a highly polymorphic family of synaptic....
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Cell
Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber, C. Jeffery Woodbury, David D. Ginty. Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic label....
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Cell
Oren Ram, Alon Goren, Ido Amit, Noam Shoresh, Nir Yosef, Jason Ernst, Manolis Kellis, Melissa Gymrek, Robbyn Issner, Michael Coyne, Timothy Durham, Xiaolan Zhang, Julie Donaghey, Charles B. Epstein, Aviv Regev, Bradley E. Bernstein. Hundreds of chromatin regulators (CRs) control chromatin structure and function by catalyzing and binding histone modifications, yet the rules governing these key processes remain obscure. Here, w....
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Cell
Roberto Chiarle, Yu Zhang, Richard L. Frock, Susanna M. Lewis, Benoit Molinie, Yu-Jui Ho, Darienne R. Myers, Vivian W. Choi, Mara Compagno, Daniel J. Malkin, Donna Neuberg, Stefano Monti, Cosmas C. Giallourakis, Monica Gostissa, Frederick W. Alt.
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Yaron Fuchs, Hermann Steller.
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Michaeleen Doucleff, Mandy Luk, Andrew Tang.
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Cell
Shunji Nakano, Bruce Stillman, H. Robert Horvitz. Although replication-coupled chromatin assembly is known to be important for the maintenance of patterns of gene expression through sequential cell divisions, the role of replication-coupled chrom....
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Cell
In This Issue
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Cell
Outnumbering our own cells by ten to one, the secret lives of our microbiota are beginning to reveal themselves through genomic analyses. This issue's Select features recent studies that begin to ....
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Cell
Sarah K. Bronson, Michael F. Verderame, Ralph L. Keil.
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Cell
Gayathri Vaidyanathan. Densely populated areas in rural China require constant vigilance and state-of-the-art technology to stop new pandemics in their tracks. Hurdles are not only scientific in some parts of the develo....
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Cell
William E. Paul. The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunol....
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Cell
Antonio Lanzavecchia, Federica Sallusto.
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Cell
Xin Liu, David A. Bushnell, Roger D. Kornberg. How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these ....
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Cell
Aseem Z. Ansari, Kimberly J. Peterson-Kaufman. Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report ....
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Cell
Agnes D. Berendsen, Bjorn R. Olsen. Cherubism, a case of bone remodeling gone haywire, is associated with mutations in the adaptor protein SH3BP2. Two papers in this issue of Cell (Guettler et al. and Levaot et al.) demonstra....
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Cell
Simone Reber, Anthony A. Hyman. Although the parts list is nearly complete for many cellular structures, mechanisms that control their size remain poorly understood. Loughlin and colleagues now show that phosphorylation of a sin....
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Cell
Junjie Hu, William A. Prinz, Tom A. Rapoport. How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are sha....
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