PubAlert » Cell » Iron-Export Ferroxidase Activity of β- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

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Cell

• September 02, 2010
• 

  Iron-Export Ferroxidase Activity of β- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

  Posted: September 2nd, 2010, 9:00pm MDT

  James A. Duce, Andrew Tsatsanis, Michael A. Cater, Simon A. James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A. Greenough, Hyun-Hee Cho, Denise Galatis, Robert D. Moir, Colin L. Masters, Catriona McLean, Rudolph E. Tanzi, Roberto Cappai, Kevin J. Barnham, Giuseppe D. Ciccotosto, Jack T. Rogers, Ashley I. Bush. Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe²⁺ elevation as well as extracellular Zn²⁺ accumulation within amyloid plaque. We found that the AD β-a....