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Current Biology
David B.T. McMahon, David A. Leopold. Humans are able to efficiently learn and remember complex visual patterns after only a few seconds of exposure [1]. At a cellular level, such learning is thought to involve changes in synaptic eff....
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Current Biology
Saskia E.J. de Vries, Thomas R. Clandinin. BackgroundMany animals extract specific cues from rich visual scenes to guide appropriate behaviors. Such cues include visual motion signals produced both by self-movement and by moving objects in....
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Current Biology
Beata Jarosiewicz, James Schummers, Wasim Q. Malik, Emery N. Brown, Mriganka Sur. BackgroundVisual perception involves information flow from lower- to higher-order cortical areas, which are known to process different kinds of information. How does this functional specialization....
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Current Biology
Tatiana Omelchenko, Alan Hall. BackgroundEpithelial tissues undergo extensive collective movements during morphogenesis, repair, and renewal. Collective epithelial cell migration requires the intercellular coordination of cell-....
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Current Biology
Ingrid Poernbacher, Roland Baumgartner, Suresh K. Marada, Kevin Edwards, Hugo Stocker. The conserved Hippo signaling pathway acts in growth control and is fundamental to animal development and oncogenesis [1–3]. Hippo signaling has also been implicated in adult midgut homeostasis in....
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Current Biology
Markus Bauer, Christian Kluge, Dominik Bach, David Bradbury, Hans Jochen Heinze, Raymond J. Dolan, Jon Driver. Cognitive processes such as visual perception and selective attention induce specific patterns of brain oscillations [1–6]. The neurochemical bases of these spectral changes in neural activity are....
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Current Biology
Raed A. Joundi, Ned Jenkinson, John-Stuart Brittain, Tipu Z. Aziz, Peter Brown. Voluntary movement is accompanied by changes in the degree to which neurons in the brain synchronize their activity within discrete frequency ranges. Two patterns of movement-related oscillatory a....
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Current Biology
Judith Zich, Alicja M. Sochaj, Heather M. Syred, Laura Milne, Atlanta G. Cook, Hiro Ohkura, Juri Rappsilber, Kevin G. Hardwick. Defects in chromosome segregation result in aneuploidy, which can lead to disease or cell death [1, 2]. The spindle checkpoint delays anaphase onset until all chromosomes are attached to spindle m....
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Current Biology
Stéphanie Durand, Nicolas Bouché, Elsa Perez Strand, Olivier Loudet, Christine Camilleri. Epigenetic variation is currently being investigated with the aim of deciphering its importance in both adaptation and evolution [1]. In plants, epimutations can underlie heritable phenotypic dive....
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Current Biology
Mayada Elsabbagh, Evelyne Mercure, Kristelle Hudry, Susie Chandler, Greg Pasco, Tony Charman, Andrew Pickles, Simon Baron-Cohen, Patrick Bolton, Mark H. Johnson. Autism spectrum disorders (henceforth autism) are diagnosed in around 1% of the population [1]. Familial liability confers risk for a broad spectrum of difficulties including the broader autism ph....
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Current Biology
George Watase, Haruhiko Takisawa, Masato T. Kanemaki. Eukaryotic DNA replication is initiated at multiple origins of replication, where many replication proteins assemble under the control of the cell cycle [1]. A key process of replication initiatio....
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Current Biology
Marie L. Smith, Frédéric Gosselin, Philippe G. Schyns. The study of internal knowledge representations is a cornerstone of the research agenda in the interdisciplinary study of cognition. An influential proposal assumes that the brain uses its interna....
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Current Biology
Qasim Zaidi, Robert Ennis, Dingcai Cao, Barry Lee. After fixating on a colored pattern, observers see a similar pattern in complementary colors when the stimulus is removed [1–6]. Afterimages were important in disproving the theory that visual ray....
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Current Biology
Sung Hugh Choi, Dannel McCollum. During mitosis, equal segregation of chromosomes depends on proper kinetochore-microtubule attachments. Merotelic kinetochore orientation, in which a single kinetochore binds microtubules from bot....
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Current Biology
Friederike Siegel, J. Alexander Heimel, Judith Peters, Christian Lohmann. Spontaneous network activity constitutes a central theme during the development of neuronal circuitry [1, 2]. Before the onset of vision, retinal neurons generate waves of spontaneous activity tha....
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Current Biology
Richard J.A. Buggs, Srikar Chamala, Wei Wu, Jennifer A. Tate, Patrick S. Schnable, Douglas E. Soltis, Pamela S. Soltis, W. Brad Barbazuk. The predictability of evolution is debatable, with recent evidence suggesting that outcomes may be constrained by gene interaction networks [1]. Whole-genome duplication (WGD; polyploidization—ubi....
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Current Biology
Sydney A. Stringham, Elisabeth E. Mulroy, Jinchuan Xing, David Record, Michael W. Guernsey, Jaclyn T. Aldenhoven, Edward J. Osborne, Michael D. Shapiro. Domestic pigeons are spectacularly diverse and exhibit variation in more traits than any other bird species [1]. In The Origin of Species, Charles Darwin repeatedly calls attention to the s....
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Current Biology
Marine Battesti, Celine Moreno, Dominique Joly, Frederic Mery. Understanding how behavioral diversity arises and is maintained is central to evolutionary biology. Genetically based inheritance has been a predominant research focus of the last century; however....
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Current Biology
Peter L. Oliver, Melanie V. Sobczyk, Elizabeth S. Maywood, Benjamin Edwards, Sheena Lee, Achilleas Livieratos, Henrik Oster, Rachel Butler, Sofia I.H. Godinho, Katharina Wulff, Stuart N. Peirson, Simon P. Fisher, Johanna E. Chesham, Janice W. Smith, Michael H. Hastings, Kay E. Davies, Russell G. Foster. Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms [2]. However, mechanistic basis for thi....
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Current Biology
Raymond C. Merritt, Uri Manor, Felipe T. Salles, M'hamed Grati, Andrea C. Dose, William C. Unrath, Omar A. Quintero, Christopher M. Yengo, Bechara Kachar. Myosin IIIA (MYO3A) targets actin protrusion tips using a motility mechanism dependent on both motor and tail actin-binding activity [1]. We show that myosin IIIB (MYO3B) lacks tail actin-binding ....
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Current Biology
Sinéad L. Mullally, Helene Intraub, Eleanor A. Maguire. BackgroundWhen we view a scene, we construct an internal representation of the scene that extends beyond its given borders. This cognitive phenomenon is revealed by a subsequent memory error when ....
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Current Biology
Qinglu Zeng, Sallie W. Chisholm. Phosphorus (P) availability, which often limits productivity in marine ecosystems, shapes the P-acquisition gene content of the marine cyanobacteria Prochlorococcus [1–4] and its viruses (c....
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Current Biology
Liliana M. Costa, Jing Yuan, Jacques Rouster, Wyatt Paul, Hugh Dickinson, Jose F. Gutierrez-Marcos. Imprinted genes are commonly expressed in mammalian placentas and in plant seed endosperms, where they exhibit preferential uniparental allelic expression. In mammals, imprinted genes directly reg....
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Current Biology
Karolina M. Pajerowska-Mukhtar, Wei Wang, Yasuomi Tada, Nodoka Oka, Chandra L. Tucker, Jose Pedro Fonseca, Xinnian Dong. BackgroundInduction of plant immune responses involves significant transcription reprogramming that prioritizes defense over growth-related cellular functions. Despite intensive forward genetic sc....
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Current Biology
Young Joon Rhee, Stephen Hillier, Geoffrey Michael Gadd. Lead (Pb) is a serious environmental pollutant in all its chemical forms [1]. Attempts have been made to immobilize lead in soil as the mineral pyromorphite using phosphate amendments (e.g., rock ....
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Current Biology
Pulak Kar, Charmaine Nelson, Anant B. Parekh. Ca2+-dependent gene expression is critical for cell growth, proliferation, plasticity, and adaptation [1–3]. Because a common mechanism in vertebrates linking cytoplasmic Ca2+
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Current Biology
Violeta Morin, Susana Prieto, Sabrina Melines, Sonia Hem, Michel Rossignol, Thierry Lorca, Julien Espeut, Nathalie Morin, Ariane Abrieu. Accurate chromosome segregation relies upon a mitotic checkpoint that monitors kinetochore attachment toward opposite spindle poles before enabling chromosome disjunction [1]. The MPS1/TTK protein....
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Current Biology
Vincent Soubannier, Gian-Luca McLelland, Rodolfo Zunino, Emelie Braschi, Peter Rippstein, Edward A. Fon, Heidi M. McBride. Mitochondrial respiration relies on electron transport, an essential yet dangerous process in that it leads to the generation of reactive oxygen species (ROS). ROS can be neutralized within the mi....
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Current Biology
Laurent Chesneau, Daphné Dambournet, Mickaël Machicoane, Ilektra Kouranti, Mitsunori Fukuda, Bruno Goud, Arnaud Echard. Cytokinesis bridge instability leads to binucleated cells that can promote tumorigenesis in vivo [1]. Membrane trafficking is crucial for animal cell cytokinesis [2–8], and several endocytic pathw....
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Current Biology
Ernő Téglás, Anna Gergely, Krisztina Kupán, Ádám Miklósi, József Topál. Recent evidence suggests that preverbal infants' gaze following can be triggered only if an actor's head turn is preceded by the expression of communicative intent [1]. Such connectedness between ....
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Current Biology
Amel Kechad, Silvana Jananji, Yvonne Ruella, Gilles R.X. Hickson. Animal cell cytokinesis proceeds via constriction of an actomyosin-based contractile ring (CR) [1, 2]. Upon reaching a diameter of ∼1 μm [3], a midbody ring (MR) forms to stabilize the intercellul....
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Current Biology
Andy Loria, Katrina M. Longhini, Michael Glotzer. Cytokinesis in animal cells is mediated by a cortical actomyosin-based contractile ring. The GTPase RhoA is a critical regulator of this process as it activates both nonmuscle myosin and a nucleat....
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Current Biology
Tristan A.F. Long, Aneil F. Agrawal, Locke Rowe. Whether the changes brought about by sexual selection are, on the whole, congruent or incongruent with the changes favored by natural selection is a fundamentally important question in evolutionar....
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Current Biology
Adam P. Morris, Michael Kubischik, Klaus-Peter Hoffmann, Bart Krekelberg, Frank Bremmer. BackgroundMany visual areas of the primate brain contain signals related to the current position of the eyes in the orbit. These cortical eye-position signals are thought to underlie the transform....
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Current Biology
Ben Vermaercke, Hans P. Op de Beeck. Although rodents are the first-choice animal model in the life sciences, they are rarely used to study higher visual functions. It is unclear to what extent rodents follow complex visual strategie....
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Current Biology
Catherine Crockford, Roman M. Wittig, Roger Mundry, Klaus Zuberbühler. The ability to recognize other individuals' mental states—their knowledge and beliefs, for example—is a fundamental part of human cognition and may be unique to our species. Tests of a “theory of ....
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Current Biology
Marta I. Garrido, Gareth R. Barnes, Maneesh Sahani, Raymond J. Dolan. The amygdala plays a central role in evaluating the behavioral importance of sensory information. Anatomical subcortical pathways provide direct input to the amygdala from early sensory systems an....
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Current Biology
Barend H.J. de Graaf, Sabina Vatovec, Javier Andrés Juárez-Díaz, Lijun Chai, Kreepa Kooblall, Katie A. Wilkins, Huawen Zou, Thomas Forbes, F. Christopher H. Franklin, Vernonica E. Franklin-Tong. Many angiosperms use specific interactions between pollen and pistil proteins as “self” recognition and/or rejection mechanisms to prevent self-fertilization. Self-incompatibility (SI) is encoded ....
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Current Biology
Marco Todesco, Sureshkumar Balasubramanian, Jun Cao, Felix Ott, Sridevi Sureshkumar, Korbinian Schneeberger, Rhonda Christiane Meyer, Thomas Altmann, Detlef Weigel. Like protein-coding genes, loci that produce microRNAs (miRNAs) are generally considered to be under purifying selection [1–3], consistent with miRNA polymorphisms being able to cause disease [4].....
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Current Biology
Patricia Kunda, Nelio T.L. Rodrigues, Emadaldin Moeendarbary, Tao Liu, Aleksandar Ivetic, Guillaume Charras, Buzz Baum. Animal cells undergo dramatic actin-dependent changes in shape as they progress through mitosis; they round up upon mitotic entry and elongate during chromosome segregation before dividing into tw....
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Current Biology
Derek T.C. Lau, Andrew W. Murray. BackgroundThe spindle checkpoint ensures accurate chromosome transmission by delaying chromosome segregation until all chromosomes are correctly aligned on the mitotic spindle. The checkpoint is a....
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Current Biology
Jinghe Liu, Gregory D. Fairn, Derek F. Ceccarelli, Frank Sicheri, Andrew Wilde. Cell division is achieved by a plasma membrane furrow that must ingress between the segregating chromosomes during anaphase [1–3]. The force that drives furrow ingression is generated by the actom....
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Current Biology
David A. Bechtold, Anissa Sidibe, Ben R.C. Saer, Jian Li, Laura E. Hand, Elena A. Ivanova, Veerle M. Darras, Julie Dam, Ralf Jockers, Simon M. Luckman, Andrew S.I. Loudon. The ability of mammals to maintain a constant body temperature has proven to be a profound evolutionary advantage, allowing members of this class to thrive in most environments on earth. Intriguin....
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Current Biology
Felicity C. Jones, Yingguang Frank Chan, Jeremy Schmutz, Jane Grimwood, Shannon D. Brady, Audrey M. Southwick, Devin M. Absher, Richard M. Myers, Thomas E. Reimchen, Bruce E. Deagle, Dolph Schluter, David M. Kingsley. Genes underlying repeated adaptive evolution in natural populations are still largely unknown. Stickleback fish (Gasterosteus aculeatus) have undergone a recent dramatic evolutionary radiat....
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Current Biology
Ewen N. MacDonald, Elizabeth K. Johnson, Jaime Forsythe, Paul Plante, Kevin G. Munhall. Species-specific vocalizations fall into two broad categories: those that emerge during maturation, independent of experience, and those that depend on early life interactions with conspecifics. H....
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Current Biology
Keiko Hirayama, Rhanor Gillette. Concrete examples of computation and implementation of cost/benefit decisions at the level of neuronal circuits are largely lacking. Such decisions are based on appetitive state, which is the inte....
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Current Biology
Erica Warp, Gautam Agarwal, Claire Wyart, Drew Friedmann, Claire S. Oldfield, Alden Conner, Filippo Del Bene, Aristides B. Arrenberg, Herwig Baier, Ehud Y. Isacoff. BackgroundDeveloping neural networks display spontaneous and correlated rhythmic bursts of action potentials that are essential for circuit refinement. In the spinal cord, it is poorly understood ....
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Current Biology
Richard Ikegami, Kristin Simokat, Hong Zheng, Louise Brown, Gian Garriga, Jeff Hardin, Joseph Culotti. BackgroundIn the last stage of the Caenorhabditis elegans body wall closure, an open pocket in the epidermis is closed by the migration of marginal epidermal P/pocket cells to the ventral m....
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Current Biology
Keith A. May, Li Zhaoping, Paul B. Hibbard. In Li and Atick's [1, 2] theory of efficient stereo coding, the two eyes' signals are transformed into uncorrelated binocular summation and difference signals, and gain control is applied to the s....
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Current Biology
Peter T. Weir, Michael H. Dickinson. Insects maintain a constant bearing across a wide range of spatial scales. Monarch butterflies and locusts traverse continents [1, 2], and foraging bees and ants travel hundreds of meters to retur....
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Current Biology
Tina Beyer, Michael Danilchik, Thomas Thumberger, Philipp Vick, Matthias Tisler, Isabelle Schneider, Susanne Bogusch, Philipp Andre, Bärbel Ulmer, Peter Walentek, Beate Niesler, Martin Blum, Axel Schweickert. In vertebrates, most inner organs are asymmetrically arranged with respect to the main body axis [1]. Symmetry breakage in fish, amphibian, and mammalian embryos depends on cilia-driven leftward f....
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Current Biology
Mathias F. Wernet, Mariel M. Velez, Damon A. Clark, Franziska Baumann-Klausener, Julian R. Brown, Martha Klovstad, Thomas Labhart, Thomas R. Clandinin. BackgroundLinearly polarized light originates from atmospheric scattering or surface reflections and is perceived by insects, spiders, cephalopods, crustaceans, and some vertebrates. Thus, the neu....
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Current Biology
Chloé Lahondère, Claudio R. Lazzari. Temperature is one of the most important factors affecting the life of insects [1]. For instance, high temperatures can have deleterious effects on insects' physiology. Therefore, many of them hav....
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Current Biology
Cesare V. Parise, Charles Spence, Marc O. Ernst. Inferring which signals have a common underlying cause, and hence should be integrated, represents a primary challenge for a perceptual system dealing with multiple sensory inputs [1–3]. This chal....
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Current Biology
Xiao-Fen Chen, Benjamin Kuryan, Tasuku Kitada, Nancy Tran, Jing-Yu Li, Siavash Kurdistani, Michael Grunstein, Bing Li, Michael Carey. The S. cerevisiae Rpd3 large (Rpd3L) and small (Rpd3S) histone deacetylase (HDAC) complexes are prototypes for understanding transcriptional repression in eukaryotes [1]. The current view i....
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Current Biology
Elizabeth S.C. Scordato, Alexa L. Bontrager, Trevor D. Price. Sexually selected traits and early breeding are often correlated with quality in birds: individuals that breed earlier in the season have more elaborate traits and raise more surviving offspring [....
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Current Biology
Orit Siton, Yaron Ideses, Shira Albeck, Tamar Unger, Alexander D. Bershadsky, Nir S. Gov, Anne Bernheim-Groswasser. Cortactin is involved in invadopodia and podosome formation [1], pathogens and endosome motility [2], and persistent lamellipodia protrusion [3, 4]; its overexpression enhances cellular motility a....
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Current Biology
Norman J. Wickett, Loren A. Honaas, Eric K. Wafula, Malay Das, Kan Huang, Biao Wu, Lena Landherr, Michael P. Timko, John Yoder, James H. Westwood, Claude W. dePamphilis. Parasitism in flowering plants has evolved at least 11 times [1]. Only one family, Orobanchaceae, comprises all major nutritional types of parasites: facultative, hemiparasitic (partially photosyn....
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Current Biology
Corinne M. Teeter, Charles F. Stevens. The tree-like structures of a neuron that are responsible for distributing (axons) or collecting (dendrites) information over a region of the brain are called arbors. The size of the territory occ....
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Current Biology
Katherine Woollett, Eleanor A. Maguire. The last decade has seen a burgeoning of reports associating brain structure with specific skills and traits (e.g., [1–8]). Although these cross-sectional studies are informative, cause and effect....
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Current Biology
Lior Ungar, Yaniv Harari, Amos Toren, Martin Kupiec. Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeric DNA is synthesized by telomerase, which is expressed only at the early stages of development [1, 2....
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Current Biology
Lara Buscemi, David Ramonet, Franco Klingberg, Aurélie Formey, Josiane Smith-Clerc, Jean-Jacques Meister, Boris Hinz. BackgroundTGF-β1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-β1 binds to the ....
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Current Biology
Seiji Tanaka, Ryuichiro Nakato, Yuki Katou, Katsuhiko Shirahige, Hiroyuki Araki. BackgroundChromosomal DNA replication in eukaryotes initiates from multiple origins of replication, and because of this multiplicity, activation of replication origins is likely to be highly coord....
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Current Biology
Libera Lo Presti, Sophie G. Martin. Kinesins and myosins transport cargos to specific locations along microtubules and actin filaments, respectively. The relative contribution of the two transport systems for cell polarization varie....
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Current Biology
Vinod K. Singaram, Benjamin H. Somerlot, Scott A. Falk, Marni J. Falk, Margaret M. Sedensky, Philip G. Morgan. Volatile anesthetics (VAs) cause profound neurological effects, including reversible loss of consciousness and immobility. Despite their widespread use, the mechanism of action of VAs remains one ....
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Current Biology
Shin-ya Takemura, Thangavel Karuppudurai, Chun-Yuan Ting, Zhiyuan Lu, Chi-Hon Lee, Ian A. Meinertzhagen. Detecting motion is a feature of all advanced visual systems [1], nowhere more so than in flying animals, like insects [2, 3]. In flies, an influential autocorrelation model for motion detection, ....
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Current Biology
Gabriela C. Monsalve, Cheryl Van Buskirk, Alison R. Frand. BackgroundBiological timing mechanisms that integrate cyclical and successive processes are not well understood. C. elegans molting cycles involve rhythmic cellular and animal behaviors lin....
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Current Biology
Tayamika Mseka, Louise P. Cramer. In migrating cells, the relative importance of myosin II contractility for cell rear retraction varies [1–12]. However, in myosin II-inhibited polarizing cells, actin organization is compromised [....
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Current Biology
Theresa C. Swayne, Chun Zhou, Istvan R. Boldogh, Joseph K. Charalel, José Ricardo McFaline-Figueroa, Sven Thoms, Christine Yang, Galen Leung, Joseph McInnes, Ralf Erdmann, Liza A. Pon. Mitochondria accumulate at neuronal and immunological synapses [1, 2] and yeast bud tips [3] and associate with the ER during phospholipid biosynthesis, calcium homeostasis, and mitochondrial fiss....
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Current Biology
Marta Rivera-Alba, Shiv N. Vitaladevuni, Yuriy Mischenko, Zhiyuan Lu, Shin-ya Takemura, Lou Scheffer, Ian A. Meinertzhagen, Dmitri B. Chklovskii, Gonzalo G. de Polavieja. Wiring economy has successfully explained the individual placement of neurons in simple nervous systems like that of Caenorhabditis elegans [1–3] and the locations of coarser structures lik....
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Current Biology
Katja Doerschner, Roland W. Fleming, Ozgur Yilmaz, Paul R. Schrater, Bruce Hartung, Daniel Kersten. Many critical perceptual judgments, from telling whether fruit is ripe to determining whether the ground is slippery, involve estimating the material properties of surfaces. Very little is known a....
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Current Biology
N. Sadananda Singh, Nan Shao, Janel R. McLean, Mayalagu Sevugan, Liping Ren, Ting Gang Chew, Andrea Bimbo, Reetu Sharma, Xie Tang, Kathleen L. Gould, Mohan K. Balasubramanian. BackgroundCytokinesis in many eukaryotes involves the function of an actomyosin-based contractile ring. In fission yeast, actomyosin ring maturation and stability require a conserved signaling pat....
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Current Biology
Els van der Helm, Justin Yao, Shubir Dutt, Vikram Rao, Jared M. Saletin, Matthew P. Walker. Clinical evidence suggests a potentially causal interaction between sleep and affective brain function; nearly all mood disorders display co-occurring sleep abnormalities, commonly involving rapid....
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Current Biology
Sung-Wan An, Seung-Kuy Cha, Joonho Yoon, Seungwoo Chang, Elliott M. Ross, Chou-Long Huang. BackgroundPLC-β signaling is generally thought to be mediated by allosteric activation by G proteins and Ca2+. Although availability of the phosphatidylinositol-4,5-biphosphate (PIP
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Current Biology
Gernot G. Supp, Markus Siegel, Joerg F. Hipp, Andreas K. Engel. Intrinsic cortical dynamics modulates the processing of sensory information and therefore may be critical for conscious perception [1–3]. We tested this hypothesis by electroencephalographic recor....
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Current Biology
Devin Blair Terhune, Sarah Tai, Alan Cowey, Tudor Popescu, Roi Cohen Kadosh. Synesthesia is an unusual condition characterized by the over-binding of two or more features and the concomitant automatic and conscious experience of atypical, ancillary images or perceptions [1....
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Current Biology
Ann M. Wehman, Corey Poggioli, Peter Schweinsberg, Barth D. Grant, Jeremy Nance. BackgroundCells release extracellular vesicles (ECVs) that can influence differentiation, modulate the immune response, promote coagulation, and induce metastasis. Many ECVs form by budding outwar....
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Current Biology
Stefano F.F. Torriani, Eva H. Stukenbrock, Patrick C. Brunner, Bruce A. McDonald, Daniel Croll. Though spliceosomal introns are a major structural component of most eukaryotic genes and intron density varies by more than three orders of magnitude among eukaryotes [1–3], the origins of intron....
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Current Biology
Suhong Xu, Andrew D. Chisholm. BackgroundRepair of skin wounds is essential for animals to survive in a harsh environment, yet the signaling pathways initiating wound repair in vivo remain little understood. In Caenorhabditi....
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Current Biology
Gregory Nachtrab, Michael Czerwinski, Kenneth D. Poss. Certain fish and amphibians regenerate entire fins and limbs after amputation, whereas such potential is absent in birds and limited in mammals to digit tips [1, 2]. Additionally, regenerative suc....
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Current Biology
Ian T. Foe, Scott A. Foster, Stephanie K. Cheung, Steven Z. DeLuca, David O. Morgan, David P. Toczyski. BackgroundCells control progression through late mitosis by regulating Cdc20 and Cdh1, the two mitotic activators of the anaphase-promoting complex (APC). The control of Cdc20 protein levels durin....
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Current Biology
Luca Santuari, Emanuele Scacchi, Antia Rodriguez-Villalon, Paula Salinas, Esther M.N. Dohmann, Géraldine Brunoud, Teva Vernoux, Richard S. Smith, Christian S. Hardtke. In the Arabidopsis root meristem, polar auxin transport creates a transcriptional auxin response gradient that peaks at the stem cell niche and gradually decreases as stem cell daughters di....
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Current Biology
Andrei P. Smertenko, Bernard Piette, Patrick J. Hussey. The phragmoplast coordinates cytokinesis in plants [1]. It directs vesicles to the midzone, the site where they coalesce to form the new cell plate. Failure in phragmoplast function results in abo....
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Current Biology
Ana Radonjić, Sarah R. Allred, Alan L. Gilchrist, David H. Brainard. Natural viewing challenges the visual system with images that have a dynamic range of light intensity (luminance) that can approach 1,000,000:1 and that often exceeds 10,000:1 [1, 2]. The range of....
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Current Biology
Sarah Zylinski, Sönke Johnsen. Animals in the lower mesopelagic zone (600–1,000 m depth) of the oceans have converged on two major strategies for camouflage: transparency and red or black pigmentation [1]. Transparency conveys ....
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Current Biology
Lukas Herwig, Yannick Blum, Alice Krudewig, Elin Ellertsdottir, Anna Lenard, Heinz-Georg Belting, Markus Affolter. Although many of the cellular and molecular mechanisms of angiogenesis have been intensely studied [1], little is known about the processes that underlie vascular anastomosis. We have generated tr....
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Current Biology
Bo W. Han, Jui-Hung Hung, Zhiping Weng, Phillip D. Zamore, Stefan L. Ameres. BackgroundMicroRNAs (miRNAs) are ∼22 nucleotide (nt) small RNAs that control development, physiology, and pathology in animals and plants. Production of miRNAs involves the sequential processing o....
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Current Biology
Michael X Cohen. The hippocampus and prefrontal cortex interact to support working memory (WM) and long-term memory [1–3]. Neurophysiologically, WM is thought to be subserved by reverberatory activity of distribut....
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Current Biology
Tom Baden, Federico Esposti, Anton Nikolaev, Leon Lagnado. BackgroundThe conversion of an analog stimulus into the digital form of spikes is a fundamental step in encoding sensory information. Here, we investigate this transformation in the visual system ....
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Current Biology
Nadine L. Wicks, Jason W. Chan, Julia A. Najera, Jonathan M. Ciriello, Elena Oancea. Exposure of human skin to solar ultraviolet radiation (UVR), a powerful carcinogen [1] comprising ∼95% ultraviolet A (UVA) and ∼5% ultraviolet B (UVB) at the Earth's surface, promotes melanin synt....
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Current Biology
Nan Liu, Masashi Abe, Leah R. Sabin, Gert-Jan Hendriks, Ammar S. Naqvi, Zhenming Yu, Sara Cherry, Nancy M. Bonini. MicroRNAs (miRNAs) are endogenous noncoding small RNAs with important roles in many biological pathways; their generation and activity are under precise regulation [1–3]. Emerging evidence suggest....
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Current Biology
Partha S. Bhagavatula, Charles Claudianos, Michael R. Ibbotson, Mandyam V. Srinivasan. Although considerable effort has been devoted to investigating how birds migrate over large distances, surprisingly little is known about how they tackle so successfully the moment-to-moment chall....
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Current Biology
Camilla U. Rang, Annie Y. Peng, Lin Chao. Single-celled organisms dividing by binary fission were thought not to age [1–4]. A 2005 study by Stewart et al. [5] reversed the dogma by demonstrating that Escherichia coli were susceptib....
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Current Biology
Johan D. Carlin, Andrew J. Calder, Nikolaus Kriegeskorte, Hamed Nili, James B. Rowe. Humans show a remarkable ability to discriminate others' gaze direction, even though a given direction can be conveyed by many physically dissimilar configurations of different eye positions and h....
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Current Biology
Volker Bischoff, Thierry Desprez, Gregory Mouille, Samantha Vernhettes, Martine Gonneau, Herman Höfte. Plant development is highly plastic and dependent on light quantity and quality monitored by specific photoreceptors. Although we have a detailed knowledge of light signaling pathways, little is k....
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Current Biology
Thomas Wernberg, Bayden D. Russell, Mads S. Thomsen, C. Frederico D. Gurgel, Corey J.A. Bradshaw, Elvira S. Poloczanska, Sean D. Connell. In recent decades, global climate change [1] has caused profound biological changes across the planet [2–6]. However, there is a great disparity in the strength of evidence among different ecosyst....
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Current Biology
Martin Dresler, Stefan P. Koch, Renate Wehrle, Victor I. Spoormaker, Florian Holsboer, Axel Steiger, Philipp G. Sämann, Hellmuth Obrig, Michael Czisch. Since the discovery of the close association between rapid eye movement (REM) sleep and dreaming, much effort has been devoted to link physiological signatures of REM sleep to the contents of asso....
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Current Biology
Boaz Sadeh, David Pitcher, Talia Brandman, Ami Eisen, Avner Thaler, Galit Yovel. Neural selectivity to specific object categories has been demonstrated in extrastriate cortex with both functional MRI [1–3] and event-related potential (ERP) [4, 5]. Here we tested for a causal r....
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Current Biology
Satomi Takeo, Cathleen M. Lake, Eurico Morais-de-Sá, Cláudio E. Sunkel, R. Scott Hawley. The pairing of homologous chromosomes and the intimate synapsis of the paired homologs by the synaptonemal complex (SC) are essential for subsequent meiotic processes including recombination and c....
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Current Biology
Nikhila S. Tanneti, Kathryn Landy, Eric F. Joyce, Kim S. McKim. Formation of the synaptonemal complex (SC), or synapsis, between homologs in meiosis is essential for crossing over and chromosome segregation [1–4]. How SC assembly initiates is poorly understood....
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