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Developmental Cell
Nadia Ranieri, Laurent Ruel, Armel Gallet, Sophie Raisin, Pascal P. Thérond. The graded Hedgehog (Hh) signal is transduced by the transmembrane Smoothened (Smo) proteins in both vertebrates and invertebrates. In Drosophila, associations between Smo and the Fused (Fu....
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Developmental Cell
Amélie Sabine, Yan Agalarov, Hélène Maby-El Hajjami, Muriel Jaquet, René Hägerling, Cathrin Pollmann, Damien Bebber, Anna Pfenniger, Naoyuki Miura, Olivier Dormond, Jean-Marie Calmes, Ralf H. Adams, Taija Mäkinen, Friedemann Kiefer, Brenda R. Kwak, Tatiana V. Petrova. Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical forces are not well understood. We found t....
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Developmental Cell
Tao Yue, Aiguo Tian, Jin Jiang. The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway c....
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Developmental Cell
Michael Lazarou, Seok Min Jin, Lesley A. Kane, Richard J. Youle. Mutations in the mitochondrial kinase PINK1 and the cytosolic E3 ligase Parkin can cause Parkinson's disease. Damaged mitochondria accumulate PINK1 on the outer membrane where, dependent on kinase....
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Developmental Cell
Maximiliano A. D'Angelo, J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H. Lackner, Martin W. Hetzer. Nuclear pore complexes (NPCs) are built from ∼30 different proteins called nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutati....
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Developmental Cell
Sung Min Han, Hiroshi Tsuda, Youfeng Yang, Jack Vibbert, Pauline Cottee, Se-Jin Lee, Jessica Winek, Claire Haueter, Hugo J. Bellen, Michael A. Miller. The VAPB/ALS8 major sperm protein domain (vMSP) is implicated in amyotrophic lateral sclerosis and spinal muscular atrophy, yet its function in the nervous system is not well understood. In Cae....
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Developmental Cell
Kaitlin M. Stimpson, Beth A. Sullivan. Eukaryotic centromeres are propagated by incorporation of the centromere-specific histone CENP-A into centromeric chromatin. Silva et al. (2012) now show that cyclin-dependent kinases (CDKs) hold ....
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Developmental Cell
Martin Behrndt, Carl-Philipp Heisenberg. How cells orchestrate their behavior during collective migration is a long-standing question. Using magnetic tweezers to apply mechanical stimuli to Xenopus mesendoderm cells, Weber et al. ....
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Developmental Cell
Robert W. Burgess, Andrew M. Garrett, Abigail L.D. Tadenev. Previous models of neuronal dendrite arborization suggested that contact-dependent self-avoidance between dendrite branches prevents self-crossings within the arbor. Two papers in Neuron sh....
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Developmental Cell
David A. Lyons, William S. Talbot. A recent Neuron paper by Zhang et al. (2012) reveals how ion channels and adhesion molecules essential for rapid nerve conduction in vertebrates are differentially targeted to nodes of Ranv....
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Developmental Cell
Michael Lenhard. The transition from cell proliferation to cell expansion is critical for determining leaf size. Andriankaja et al. (2012) demonstrate that in leaves of dicotyledonous plants, a basal proliferation....
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Developmental Cell
David Bilder, Saori L. Haigo. Tissue and organ architectures are incredibly diverse, yet our knowledge of the morphogenetic behaviors that generate them is relatively limited. Recent studies have revealed unexpected mechanisms....
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Developmental Cell
Jianshe Yan, Vassil Mihaylov, Xuehua Xu, Joseph A. Brzostowski, Hongyan Li, Lunhua Liu, Timothy D. Veenstra, Carole A. Parent, Tian Jin. Activation of G protein-coupled receptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into Gα and Gβγ subunits, which go on to regulate various effectors involved in a panoply o....
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Developmental Cell
Narendra Thapa, Yue Sun, Mark Schramp, Suyong Choi, Kun Ling, Richard A. Anderson. Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP2-synthesizing enzyme, PIP....
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Developmental Cell
Xiao Lei Chen, Ju-Ock Nam, Christine Jean, Christine Lawson, Colin T. Walsh, Erik Goka, Ssang-Taek Lim, Alok Tomar, Isabelle Tancioni, Sean Uryu, Jun-Lin Guan, Lisette M. Acevedo, Sara M. Weis, David A. Cheresh, David D. Schlaepfer. Endothelial cells (ECs) form cell-cell adhesive junctional structures maintaining vascular integrity. This barrier is dynamically regulated by vascular endothelial growth factor (VEGF) receptor si....
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Developmental Cell
Cristina Pallares-Cartes, Gulcin Cakan-Akdogan, Aurelio A. Teleman. PRAS40 has recently been identified as a protein that couples insulin/IGF signaling (IIS) to TORC1 activation in cell culture; however, the physiological function of PRAS40 is not known. In this s....
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Developmental Cell
Eike H. Rademacher, Annemarie S. Lokerse, Alexandra Schlereth, Cristina I. Llavata-Peris, Martin Bayer, Marika Kientz, Alejandra Freire Rios, Jan Willem Borst, Wolfgang Lukowitz, Gerd Jürgens, Dolf Weijers. The cell types of the plant root are first specified early during embryogenesis and are maintained throughout plant life. Auxin plays an essential role in embryonic root initiation, in part throug....
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Developmental Cell
Benjamin L. Martin, David Kimelman. The vertebrate body forms in an anterior-to-posterior progression, driven by a population of undifferentiated cells at the posterior-most end of the embryo. Recent studies have demonstrated that t....
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Developmental Cell
Eran Meshorer, Dhananjay Yellajoshula, Eric George, Peter J. Scambler, David T. Brown, Tom Misteli.
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Developmental Cell
Hyun Kyoung Lee, Benjamin Deneen. The Daam family of proteins consists of Daam1 and Daam2. Although Daam1 participates in noncanonical Wnt signaling during gastrulation, Daam2 function remains completely uncharacterized. Here we d....
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Developmental Cell
Megan Andriankaja, Stijn Dhondt, Stefanie De Bodt, Hannes Vanhaeren, Frederik Coppens, Liesbeth De Milde, Per Mühlenbock, Aleksandra Skirycz, Nathalie Gonzalez, Gerrit T.S. Beemster, Dirk Inzé. Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expressio....
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Developmental Cell
Reiner Wimmer, Botond Cseh, Barbara Maier, Karina Scherrer, Manuela Baccarini. Sprouting angiogenesis, crucial for the development of new blood vessels, is a prime example of collective migration in which endothelial cells migrate as a group joined via cadherin-containing ad....
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Developmental Cell
Linda N. Geng, Zizhen Yao, Lauren Snider, Abraham P. Fong, Jennifer N. Cech, Janet M. Young, Silvere M. van der Maarel, Walter L. Ruzzo, Robert C. Gentleman, Rabi Tawil, Stephen J. Tapscott. Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular dystrophies. The causative gene remains controversial and the mechanism of pathophysiology unknown. Here we identi....
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Developmental Cell
Marta A. Dozynkiewicz, Nigel B. Jamieson, Iain MacPherson, Joan Grindlay, Peter V.E. van den Berghe, Anne von Thun, Jennifer P. Morton, Charlie Gourley, Paul Timpson, Colin Nixon, Colin J. McKay, Ross Carter, David Strachan, Kurt Anderson, Owen J. Sansom, Patrick T. Caswell, Jim C. Norman. Here we show that Rab25 permits the sorting of ligand-occupied, active-conformation α5β1 integrin to late endosomes/lysosomes. Photoactivation and biochemical approaches show that lysosomally targ....
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Developmental Cell
Seunghee Lee, Jae W. Lee, Soo-Kyung Lee. The removal of histone H3 lysine27 (H3K27) trimethylation mark is important for the robust induction of many cell type-specific genes during differentiation. Here we show that UTX, a H3K27 demethy....
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Developmental Cell
Shigeki Yoshiura, Nao Ohta, Fumio Matsuzaki. During development, directional cell division is a major mechanism for establishing the orientation of tissue growth. Drosophila neuroblasts undergo asymmetric divisions perpendicular to th....
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Developmental Cell
David Merrick, Hannah Chapin, Julie E. Baggs, Zhiheng Yu, Stefan Somlo, Zhaoxia Sun, John B. Hogenesch, Michael J. Caplan. Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-me....
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Developmental Cell
Carl S. Thummel. Genetic studies of Drosophila eye imaginal disc development have provided a classic approach to dissect the coordination of cell proliferation and differentiation. This paper describes the ....
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Developmental Cell
Erwin F. Wagner. I very much enjoyed reading a Developmental Cell paper from Freddy Radtke's laboratory describing exciting findings regarding the requirement of Notch1 signaling for maintenance of corneal ....
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Developmental Cell
Shelby A. Blythe, Peter S. Klein. Recent work has raised the possibility that chromatin modifications pre-set embryonic patterns of gene expression. In this issue of Developmental Cell, Lindeman et al. (2011) support this o....
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Developmental Cell
Bruce A. Hamilton, Xiang-Dong Fu. Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled splicin....
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Developmental Cell
Rebecca Bastock, Daniel St Johnston. The entry of the sperm centrosome polarizes the anterior-posterior axis of the C. elegans zygote by inducing the formation of complementary cortical Par protein domains. Recent papers from ....
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Developmental Cell
Jormay Lim, Jean Paul Thiery. The epithelial-to-mesenchymal transition (EMT), a key process in morphogenesis, is often driven by repressing expression of adherens junction components, such as E-cadherin. In this issue of De....
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Developmental Cell
Grégory Vert, Joanne Chory. During the past two decades, molecular biologists and geneticists have deconstructed intracellular signaling pathways in individual cells, revealing a great deal of crosstalk among key signaling p....
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Developmental Cell
Stephen Frankenberg, François Gerbe, Sylvain Bessonnard, Corinne Belville, Pierre Pouchin, Olivier Bardot, Claire Chazaud. During preimplantation mouse development, the inner cell mass (ICM) differentiates into two cell lineages—the epiblast and the primitive endoderm (PrE)—whose precursors are identifiable by recipro....
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Developmental Cell
Wenwen Tang, Yong Zhang, Wenwen Xu, T. Kendall Harden, John Sondek, Le Sun, Lin Li, Dianqing Wu. Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for che....
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Developmental Cell
Kyra Campbell, Gavin Whissell, Xavier Franch-Marro, Eduard Batlle, Jordi Casanova. The epithelial-to-mesenchymal transition (EMT) converts cells from static epithelial to migratory mesenchymal states (Hay, 1995). Here, we demonstrate that EMT in the Drosophila endoderm is....
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Developmental Cell
Carolyn R. Dombecki, Ason C.Y. Chiang, Hyun-Joo Kang, Ceyda Bilgir, Nicholas A. Stefanski, Bryan J. Neva, Elke P.F. Klerkx, Kentaro Nabeshima. Homologous chromosome pairing is a prerequisite to establish physical linkage between homologs, which is critical for faithful chromosome segregation during meiosis I. The establishment of pairing....
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Developmental Cell
Kuan-Chung Su, Tohru Takaki, Mark Petronczki. In animal cells, formation of the cytokinetic furrow requires activation of the GTPase RhoA by the guanine nucleotide exchange factor Ect2. How Ect2, which is associated with the spindle midzone, ....
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Developmental Cell
E. Lechner, N. Leonhardt, H. Eisler, Y. Parmentier, M. Alioua, H. Jacquet, J. Leung, P. Genschik. Being sessile organisms, plants need rapid and finely tuned signaling pathways to adapt their growth and survival over their immediate and often adverse environment. Abscisic acid (ABA) is a plant....
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Developmental Cell
Anne Vatén, Jan Dettmer, Shuang Wu, York-Dieter Stierhof, Shunsuke Miyashima, Shri Ram Yadav, Christina J. Roberts, Ana Campilho, Vincent Bulone, Raffael Lichtenberger, Satu Lehesranta, Ari Pekka Mähönen, Jae-Yean Kim, Eija Jokitalo, Norbert Sauer, Ben Scheres, Keiji Nakajima, Annelie Carlsbecker, Kimberly L. Gallagher, Ykä Helariutta. Plant cells are connected through plasmodesmata (PD), membrane-lined channels that allow symplastic movement of molecules between cells. However, little is known about the role of PD-mediated sign....
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Developmental Cell
Yui Jin, Azmiri Sultana, Pallavi Gandhi, Edward Franklin, Susan Hamamoto, Amir R. Khan, Mary Munson, Randy Schekman, Lois S. Weisman. Vesicle transport requires four steps: vesicle formation, movement, tethering, and fusion. In yeast, two Rab GTPases, Ypt31/32, are required for post-Golgi vesicle formation. A third Rab GTPase, S....
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Developmental Cell
Cláudia Rosa-Ferreira, Sean Munro. Lysosomes move bidirectionally on microtubules, and this motility can be stimulated by overexpression of the small GTPase Arl8. By using affinity chromatography, we find that Arl8-GTP binds to the....
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Developmental Cell
Roger B. Deal, Steven Henikoff.
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Developmental Cell
Carl J. DeSelm, Brian C. Miller, Wei Zou, Wandy L. Beatty, Eline van Meel, Yoshifumi Takahata, Judith Klumperman, Sharon A. Tooze, Steven L. Teitelbaum, Herbert W. Virgin.
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Developmental Cell
Gregory F. Weber, Maureen A. Bjerke, Douglas W. DeSimone. Collective cell migration requires maintenance of adhesive contacts between adjacent cells, coordination of polarized cell protrusions, and generation of propulsive traction forces. We demonstrate....
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Developmental Cell
Mariana C.C. Silva, Dani L. Bodor, Madison E. Stellfox, Nuno M.C. Martins, Helfrid Hochegger, Daniel R. Foltz, Lars E.T. Jansen. Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Prop....
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Developmental Cell
Leif C. Lindeman, Ingrid S. Andersen, Andrew H. Reiner, Nan Li, Håvard Aanes, Olga Østrup, Cecilia Winata, Sinnakaruppan Mathavan, Ferenc Müller, Peter Aleström, Philippe Collas. A hallmark of anamniote vertebrate development is a window of embryonic transcription-independent cell divisions before onset of zygotic genome activation (ZGA). Chromatin determinants of ZGA are ....
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Developmental Cell
Zhigang Tu, Katherine M. Aird, Benjamin G. Bitler, Jasmine P. Nicodemus, Neil Beeharry, Bing Xia, Tim J. Yen, Rugang Zhang. Here, we report a cell-intrinsic mechanism by which oncogenic RAS promotes senescence while predisposing cells to senescence bypass by allowing for secondary hits. We show that oncogenic RAS inact....
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Developmental Cell
Carlos Carmona-Fontaine, Eric Theveneau, Apostolia Tzekou, Masazumi Tada, Mae Woods, Karen M. Page, Maddy Parsons, John D. Lambris, Roberto Mayor. Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutua....
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Developmental Cell
Mingjia Tan, Yongchao Zhao, Sun-Jung Kim, Margaret Liu, Lijun Jia, Thomas L. Saunders, Yuan Zhu, Yi Sun. SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and....
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Developmental Cell
Takiko Daikoku, Jeeyeon Cha, Xiaofei Sun, Susanne Tranguch, Huirong Xie, Tomoko Fujita, Yasushi Hirota, John Lydon, Francesco DeMayo, Robert Maxson, Sudhansu K. Dey. An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when t....
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Developmental Cell
Birgit Kagermeier-Schenk, Daniel Wehner, Günes Özhan-Kizil, Hideki Yamamoto, Jian Li, Katharina Kirchner, Christian Hoffmann, Peter Stern, Akira Kikuchi, Alexandra Schambony, Gilbert Weidinger. Wnt proteins can activate distinct signaling pathways, but little is known about the mechanisms regulating pathway selection. Here we show that the metastasis-associated transmembrane protein Wnt-....
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Developmental Cell
Joan Brugge. Prior to the publication of this report, the importance of endocytotic and exocytotic recycling of integrins was just beginning to be recognized. However, the findings in this report provided sign....
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Developmental Cell
Helmut Krämer. The paper by Kobayashi et al. triggered fond memories and curious questions, as one might expect when meeting a couple of old, almost forgotten friends. As a post doc in Larry Zipursky's laborator....
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Developmental Cell
Sue L. Jaspersen, R. Scott Hawley. In C. elegans, meiotic chromosome pairing is initiated by association of chromosomal sites known as pairing centers (PCs) with the nuclear periphery. The Dernburg and Zetka laboratories hav....
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Developmental Cell
Nicole E. Follmer, Nicole J. Francis. During mitosis, most transcription ceases. Mitotic gene bookmarking marks genes for reactivation to ensure reestablishment of transcription states and cell-cycle progression. In a recent issue of ....
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Developmental Cell
Amir Gelman, Zvulun Elazar. Autophagy is an intracellular membrane-trafficking pathway for the delivery of proteins and organelles to lysosomes for degradation and recycling. DeSelm and coworkers (2011) now describe an essen....
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Developmental Cell
Vytas A. Bankaitis, Aby Grabon. Kim et al. (2011) challenge the dogma that phosphatidylinositol synthesis is restricted to the endoplasmic reticulum (ER) by showing that a mobile membrane compartment transports phosphatidylinosi....
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Developmental Cell
Yeun Ju Kim, Maria Luisa Guzman-Hernandez, Tamas Balla. Polyphosphoinositides are lipid signaling molecules generated from phosphatidylinositol (PtdIns) with critical roles in vesicular trafficking and signaling. It is poorly understood where PtdIns is....
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Developmental Cell
Haijiao Wang, Cangjin Yang, Chi Zhang, Niyan Wang, Dihong Lu, Jie Wang, Shanshan Zhang, Zhi-Xin Wang, Hong Ma, Xuelu Wang. The plasma membrane-localized plant steroid hormone receptor, BRASSINOSTEROID INSENSITIVE 1 (BRI1), is quiescent in the absence of steroids, largely due to a negative regulator, BRI1 KINASE INHIBI....
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Developmental Cell
Julian C. Boggiano, Pamela J. Vanderzalm, Richard G. Fehon. Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive signals are transdu....
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Developmental Cell
Carole L.C. Poon, Jane I. Lin, Xiaomeng Zhang, Kieran F. Harvey. The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we ....
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Developmental Cell
Mary Madabhushi, Elizabeth Lacy. In amniotes, ventral folding morphogenesis achieves gut internalization, linear heart tube formation, ventral body wall closure, and encasement of the fetus in extraembryonic membranes. Impairment....
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Developmental Cell
Sapan R. Gandhi, Marek Gierliński, Akihisa Mino, Kozo Tanaka, Etsushi Kitamura, Lesley Clayton, Tomoyuki U. Tanaka. How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When....
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Developmental Cell
Jennifer R. Hom, Rodrigo A. Quintanilla, David L. Hoffman, Karen L. de Mesy Bentley, Jeffery D. Molkentin, Shey-Shing Sheu, George A. Porter.
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Developmental Cell
Carl J. DeSelm, Brian C. Miller, Wei Zou, Wandy L. Beatty, Eline van Meel, Yoshifumi Takahata, Judith Klumperman, Sharon A. Tooze, Steven L. Teitelbaum, Herbert W. Virgin. Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the plasmalemma results in a....
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Developmental Cell
David Jukam, Claude Desplan. Patterning the Drosophila retina for color vision relies on postmitotic specification of photoreceptor subtypes. R8 photoreceptors express one of two light-sensing Rhodopsins, Rh5 or Rh6. T....
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Developmental Cell
Stéphanie Torrino, Orane Visvikis, Anne Doye, Laurent Boyer, Caroline Stefani, Patrick Munro, Jacques Bertoglio, Gérard Gacon, Amel Mettouchi, Emmanuel Lemichez. Rac1 small GTPase controls essential aspects of cell biology and is a direct target of numerous bacterial virulence factors. The CNF1 toxin of pathogenic Escherichia coli addresses Rac1 to ....
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Developmental Cell
Jun Shi, Liqing Luo, John Eash, Chikwendu Ibebunjo, David J. Glass. Insulin-like growth factor 1 (IGF1) induces skeletal muscle hypertrophy by activating the IGF1R/IRS1/PI3K/Akt pathway. However the effect of IGF1 in differentiated muscle is limited by IRS1 ubiqui....
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Developmental Cell
Sara Labella, Alexander Woglar, Verena Jantsch, Monique Zetka. During meiosis, chromosomes must find and align with their homologous partners. SUN and KASH-domain protein pairs play a conserved role by establishing transient linkages between chromosome ends a....
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Developmental Cell
Nicola C. Harper, Regina Rillo, Sara Jover-Gil, Zoe June Assaf, Needhi Bhalla, Abby F. Dernburg. Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In C. elegans, homolog pairing and synapsis depend on pairing centers (PCs), spe....
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Developmental Cell
Norbert Perrimon. Large-scale studies in various model systems including Drosophila, fish, and the mouse have documented the exquisite temporal and spatial expression patterns of thousands of genes during de....
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Developmental Cell
Patrick Tam. This study illustrates how the combination of innovative genetic mouse models, embryological experimentation, and live-imaging techniques can resolve longstanding questions in endoderm formation d....
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Developmental Cell
Johannes M. Herrmann. Cristae junctions mark the boundaries of respiratory compartments in the inner mitochondrial membrane. In this issue of Developmental Cell, von der Malsburg et al. (2011) identify a complex....
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Developmental Cell
Aurnab Ghose, L.S. Shashidhara. In this issue of Developmental Cell, Odajima, Wills, and colleagues (2011) demonstrate that the cell-cycle regulator, cyclin E, sequesters Cdk5, a key regulator of neuronal development and synapti....
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Developmental Cell
Anna Cariboni, Christiana Ruhrberg. Neurovascular integration during embryonic development is essential for adult physiology. In this issue of Developmental Cell, Gutnick et al. (2011) report that hypothalamic neurons secrete....
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Developmental Cell
Vladimir Lizunov, Petr Chlanda, Mary Kraft, Joshua Zimmerberg. The mechanistic basis of how cells respond to increased fatty acids (FAs) is murky but potentially involves receptor-mediated activation or inhibition by different FA classes. Holzer et al. (2011)....
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Developmental Cell
Raj K. Ladher. The earliest steps in tooth development depend on signaling interactions that result in the condensation of mandibular mesenchyme into the tooth bud. Reporting in this issue of Developmental Ce....
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Developmental Cell
Anna N. Stepanova, Jose M. Alonso. In this issue of Developmental Cell, Marhavý et al. (2011) uncover a transcription-independent molecular mechanism of interaction between auxin and cytokinin in the regulation of plant meri....
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Developmental Cell
Mark D. Biggin. To understand how transcription factors function, it is essential to determine the range of genes that they each bind and regulate in vivo. Here I review evidence that most animal transcription fa....
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Developmental Cell
Amos Gutnick, Janna Blechman, Jan Kaslin, Lukas Herwig, Heinz-Georg Belting, Markus Affolter, Joshua L. Bonkowsky, Gil Levkowitz. The hypothalamo-neurohypophyseal system (HNS) is the neurovascular structure through which the hypothalamic neuropeptides oxytocin and arginine-vasopressin exit the brain into the bloodstream, whe....
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Developmental Cell
Ashwin Seetharaman, Guillermo Selman, Rachel Puckrin, Louis Barbier, Eric Wong, Serena A. D'Souza, Peter J. Roy. The netrins and slits are two families of widely conserved cues that guide axons and cells along the dorsal-ventral (D-V) axis of animals. These cues typically emanate from the dorsal or ventral m....
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Developmental Cell
Qing Deng, Sa Kan Yoo, Peter J. Cavnar, Julie M. Green, Anna Huttenlocher. Neutrophil homeostasis is essential for host defense. Here we identify dual roles for Rac2 during neutrophil homeostasis using a zebrafish model of primary immune deficiency induced by the human i....
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Developmental Cell
Yoontae Lee, John D. Fryer, Hyojin Kang, Juan Crespo-Barreto, Aaron B. Bowman, Yan Gao, Juliette J. Kahle, Jeong Soo Hong, Farrah Kheradmand, Harry T. Orr, Milton J. Finegold, Huda Y. Zoghbi. Although expansion of CAG repeats in ATAXIN1 (ATXN1) causes Spinocerebellar ataxia type 1, the functions of ATXN1 and ATAXIN1-Like (ATXN1L) remain poorly understood. To investigate t....
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Developmental Cell
Anjali S. Iyer-Pascuzzi, Terry Jackson, Hongchang Cui, Jalean J. Petricka, Wolfgang Busch, Hironaka Tsukagoshi, Philip N. Benfey. Stress responses in plants are tightly coordinated with developmental processes, but interaction of these pathways is poorly understood. We used genome-wide assays at high spatiotemporal resolutio....
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Developmental Cell
Alysia Vrailas-Mortimer, Tania del Rivero, Subhas Mukherjee, Sanjay Nag, Alexandros Gaitanidis, Dimitris Kadas, Christos Consoulas, Atanu Duttaroy, Subhabrata Sanyal. Molecular mechanisms that concordantly regulate stress, life span, and aging remain incompletely understood. Here, we demonstrate that in Drosophila, a p38 MAP kinase (p38K)/Mef2/MnSOD path....
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Developmental Cell
Victoria E. Ahn, Matthew Ling-Hon Chu, Hee-Jung Choi, Denise Tran, Arie Abo, William I. Weis. LDL receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Wnt growth factors, and also bind Dkk proteins, secreted inhibitors of Wnt signaling. The LRP5/6 ectodomain contains four β-prope....
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Developmental Cell
Shuo Chen, Doryen Bubeck, Bryan T. MacDonald, Wen-Xue Liang, Jian-Hua Mao, Tomas Malinauskas, Oscar Llorca, A. Radu Aricescu, Christian Siebold, Xi He, E. Yvonne Jones. LDL-receptor-related protein 6 (LRP6), alongside Frizzled receptors, transduces Wnt signaling across the plasma membrane. The LRP6 ectodomain comprises four tandem β-propeller–EGF-like domain (PE)....
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Developmental Cell
Elisabetta Ferretti, Bingsi Li, Rediet Zewdu, Victoria Wells, Jean M. Hebert, Courtney Karner, Matthew J. Anderson, Trevor Williams, Jill Dixon, Michael J. Dixon, Michael J. Depew, Licia Selleri. Morphogenesis of mammalian facial processes requires coordination of cellular proliferation, migration, and apoptosis to develop intricate features. Cleft lip and/or palate (CL/P), the most freque....
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Developmental Cell
Mark D. Bass, Rosalind C. Williamson, Robert D. Nunan, Jonathan D. Humphries, Adam Byron, Mark R. Morgan, Paul Martin, Martin J. Humphries. Cell migration during wound healing requires adhesion receptor turnover to enable the formation and disassembly of cell-extracellular matrix contacts. Although recent advances have improved our un....
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Developmental Cell
Peter Marhavý, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jerome Duclercq, Hirokazu Tanaka, Markéta Pařezová, Jan Petrášek, Jiří Friml, Jürgen Kleine-Vehn, Eva Benková. Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regu....
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Developmental Cell
Guillaume van Niel, Stéphanie Charrin, Sabrina Simoes, Maryse Romao, Leila Rochin, Paul Saftig, Michael S. Marks, Eric Rubinstein, Graça Raposo. Cargo sorting to intraluminal vesicles (ILVs) of multivesicular endosomes is required for lysosome-related organelle (LRO) biogenesis. PMEL—a component of melanocyte LROs (melanosomes)—is sorted t....
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Developmental Cell
Junko Odajima, Zachary P. Wills, Yasmine M. Ndassa, Miho Terunuma, Karla Kretschmannova, Tarek Z. Deeb, Yan Geng, Sylwia Gawrzak, Isabel M. Quadros, Jennifer Newman, Manjusri Das, Marie E. Jecrois, Qunyan Yu, Na Li, Frederic Bienvenu, Stephen J. Moss, Michael E. Greenberg, Jarrod A. Marto, Piotr Sicinski. Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is norm....
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Developmental Cell
Karina von der Malsburg, Judith M. Müller, Maria Bohnert, Silke Oeljeklaus, Paulina Kwiatkowska, Thomas Becker, Adrianna Loniewska-Lwowska, Sebastian Wiese, Sanjana Rao, Dusanka Milenkovic, Dana P. Hutu, Ralf M. Zerbes, Agnes Schulze-Specking, Helmut E. Meyer, Jean-Claude Martinou, Sabine Rospert, Peter Rehling, Chris Meisinger, Marten Veenhuis, Bettina Warscheid, Ida J. van der Klei, Nikolaus Pfanner, Agnieszka Chacinska, Martin van der Laan. The mitochondrial inner membrane consists of two domains, inner boundary membrane and cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be involved in formati....
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Developmental Cell
Tadanori Mammoto, Akiko Mammoto, Yu-suke Torisawa, Tracy Tat, Ashley Gibbs, Ratmir Derda, Robert Mannix, Marlieke de Bruijn, Chong Wing Yung, Dongeun Huh, Donald E. Ingber. Mesenchymal condensation is critical for organogenesis, yet little is known about how this process is controlled. Here we show that Fgf8 and Sema3f, produced by early dental epithelium, respective....
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Developmental Cell
Ang Li, Yafeng Ma, Xinzi Yu, Richard L. Mort, Colin R. Lindsay, David Stevenson, Douglas Strathdee, Robert H. Insall, Jonathan Chernoff, Scott B. Snapper, Ian J. Jackson, Lionel Larue, Owen J. Sansom, Laura M. Machesky. During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis cau....
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Developmental Cell
Sarah E. Millar. Knockout mice are the gold standard for understanding gene function—or are they? The phenotypes of Egfl7 knockout mice and morphant fish suggested a critical and unexpected role for this se....
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Developmental Cell
Richard Harvey. The paper by Kelly et al., from Margaret Buckingham's group at the Pasteur Institute in Paris, changed the way we think about the developing mammalian heart, as well as the origins of congenital h....
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Developmental Cell
J. Bradley Zuchero, Ben A. Barres. Myelin is a lipid-rich, spiraled membrane structure that allows for rapid propagation of action potentials through axons. In this issue, Aggarwal et al. (2011) present evidence that myelin basic p....
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