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EMBO reports (100 unread)

• February 01, 2012
• 7:34

  Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1

   » ‎ EMBO reports

  Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1

  EMBO Reports 13, 163 (2012). doi:10.1038/embor.2011.235

  Authors: Deresa Lee, Sang-Joon Park, Ki Sa Sung, Jikyoung Park, Sean Bong Lee, Sang-Yoon Park, Hyo Jeong Lee, Jang-Won Ahn, So Jung Choi, Seok-Geun Lee, Sung-Hoon Kim, Duk-Hwan Kim, Jhingook Kim, Yongsok Kim & Cheol Yong Choi

  The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear. Here we show that NORE1 induces polyubiquitination and proteasomal degradation of oncoprotein HIPK1 by facilitating its interaction with the Mdm2 E3 ubiquitin ligase. Endogenous HIPK1

  
• 7:34

  All Chinese to me

   » ‎ EMBO reports

  All Chinese to me

  EMBO Reports 13, 91 (2012). doi:10.1038/embor.2011.250

  Author: Howy Jacobs

  An old joke goes something like this: in heaven the police are British, the chefs are French, the lovers are Italian, the engineers are German and the government is run by the Swiss. In hell, the chefs are British, the lovers Swiss, the mechanics French,

  
• 7:34

  Synthetic biology's flywheel

   » ‎ EMBO reports

  Synthetic biology's flywheel

  EMBO Reports 13, 92 (2012). doi:10.1038/embor.2011.253

  Author: Antoine Danchin

  The invention of the steam engine triggered the industrial revolution. However, the first commercial engines of the early eighteenth century produced only linear movements, parallel to the movement of the piston in the cylinder. They were therefore only suitable for a few limited applications. It

  
• 7:34

  Neutrophils—the unexpected helpers of B-cell activation

   » ‎ EMBO reports

  Neutrophils—the unexpected helpers of B-cell activation

  EMBO Reports 13, 93 (2012). doi:10.1038/embor.2011.259

  Authors: Naomi E Harwood, Patricia Barral & Facundo D Batista

  

• 7:34

  Inside an unquiet mind

   » ‎ EMBO reports

  Inside an unquiet mind

  EMBO Reports 13, 95 (2012). doi:10.1038/embor.2011.255

  Authors: Hanna M Critchlow, Paul Herrington & Simon Gunton

  Science is dramatic and scientific discoveries are almost always emotional journeys. The effect of scientific progress on societies and individuals can similarly be profound, especially where it improves lives by providing new treatments or by offering greater understanding of illness. The challenge is to communicate

  
• 7:34

  The anglerfish deception

   » ‎ EMBO reports

  The anglerfish deception

  EMBO Reports 13, 100 (2012). doi:10.1038/embor.2011.254

  Authors: Fern Wickson & Brian Wynne

  Anglerfish are predators that live in the eternal darkness of the deep oceans and have a distinctive way of catching their prey. They use a long light-emitting filament that extends from their head to lure organisms in the darkness. Those attracted to the shimmering light

  
• 7:34

  Emerging journals

   » ‎ EMBO reports

  Emerging journals

  EMBO Reports 13, 106 (2012). doi:10.1038/embor.2011.252

  Author: Rogerio Meneghini

  Since the first scientific journal was founded—The Philosophical Transactions of the Royal Society in 1665—the number of journals dedicated to publishing academic research has literally exploded. The Thomson Reuters Web of Knowledge database alone—which represents far less than the total number of academic

  
• 7:34

  Research and practice coming together

   » ‎ EMBO reports

  Research and practice coming together

  EMBO Reports 13, 109 (2012). doi:10.1038/embor.2011.258

  Author: Philip Hunter

  In the early days of synthetic drugs, just after the discovery of penicillin, doctors knew very little about pharmaceuticals and simply followed the manufacturer's ‘advice’ when prescribing them for patients. This made sense in a period when pills were almost worshipped as panaceas for whatever

  
• 7:34

  Regulation and function of innate and adaptive interleukin-17-producing cells

   » ‎ EMBO reports

  Regulation and function of innate and adaptive interleukin-17-producing cells

  EMBO Reports 13, 113 (2012). doi:10.1038/embor.2011.248

  Authors: Keiji Hirota, Helena Ahlfors, João H Duarte & Brigitta Stockinger

  Interleukin-17 (IL-17)-mediated immune responses play a crucial role in the mucosal host defence against microbial and fungal pathogens. However, the chronic activation of IL-17-producing T helper cells can cause autoimmune disease. In addition, recent studies have highlighted key roles of innate cell-mediated IL-17 responses in

  
• 7:34

  Regulation of TOR by small GTPases

   » ‎ EMBO reports

  Regulation of TOR by small GTPases

  EMBO Reports 13, 121 (2012). doi:10.1038/embor.2011.257

  Authors: Raúl V Durán & Michael N Hall

  TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles

  
• 7:34

  Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β

   » ‎ EMBO reports

  Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β

  EMBO Reports 13, 129 (2012). doi:10.1038/embor.2011.240

  Authors: Anja Kietzmann, Yingqun Wang, Dominik Weber & Herbert Steinbeisser

  Xenopus paraxial protocadherin (PAPC) regulates cadherin-mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β-catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2

  
• 7:34

  ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

   » ‎ EMBO reports

  ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

  EMBO Reports 13, 135 (2012). doi:10.1038/embor.2011.243

  Authors: Jean-Yves Bleuyard, Rémi Buisson, Jean-Yves Masson & Fumiko Esashi

  The partner and localizer of breast cancer 2 susceptibility protein (PALB2) is crucial for the repair of DNA damage by homologous recombination. Here, we report that chromatin-association motif (ChAM), an evolutionarily conserved motif in PALB2, is necessary and sufficient to mediate its chromatin association in

  
• 7:34

  Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

   » ‎ EMBO reports

  Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

  EMBO Reports 13, 142 (2012). doi:10.1038/embor.2011.247

  Authors: Taeko Wada, Jiro Kikuchi & Yusuke Furukawa

  Relatively little is known about the regulatory mechanisms of the Drosha/DGCR8 complex, which processes miRNAs at the initial step of biogenesis. We found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes. HDAC1 is an

  
• 7:34

  Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

   » ‎ EMBO reports

  Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

  EMBO Reports 13, 150 (2012). doi:10.1038/embor.2011.246

  Authors: Jeongho Kwon, Eunhye Han, Chi-Bao Bui, Woochul Shin, Junho Lee, Sejeong Lee, Young-Bong Choi, Ann-Hwee Lee, Kyong-Hoon Lee, Chankyu Park, Martin S Obin, Sung Kyu Park, Yun Jeong Seo, Goo Taeg Oh, Han-Woong Lee & Jaekyoon Shin

  Sqstm1/p62 functions in the non-canonical activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). However, its physiological relevance is not certain. Here, we show that p62−/− mice exhibited an accelerated presentation of ageing phenotypes, and tissues from these mice created a pro-oxidative environment

  
• 7:34

  Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth

   » ‎ EMBO reports

  Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth

  EMBO Reports 13, 157 (2012). doi:10.1038/embor.2011.230

  Authors: Fabrizio Rossi & Cayetano Gonzalez

  Loss of function of pins (partner of inscuteable) partially disrupts neuroblast (NB) polarity and asymmetric division, results in fewer and smaller NBs and inhibits Drosophila larval brain growth. Food deprivation also inhibits growth. However, we find that the combination of loss of function

  
• December 24, 2011
• 20:10

  Happy birthday to RU

   » ‎ EMBO reports

  Happy birthday to RU

  EMBO Reports 13, 1 (2012). doi:10.1038/embor.2011.228

  Author: Howy Jacobs

  Twenty years after the implosion of the Soviet Union, a significant hole in the world map of science remains. Russia, one of the great civilizations of Europe, produces far less scientific output than comparable nations: in biosciences, The Netherlands publishes three times as many papers

  
• 20:10

  Stem cells, morals and the courts

   » ‎ EMBO reports

  Stem cells, morals and the courts

  EMBO Reports 13, 2 (2012). doi:10.1038/embor.2011.242

  Author: Michele Garfinkel

  Earlier this year, the European Court of Justice revoked a patent on how to generate nerve cells from human embryonic stem cells. The decision raises intriguing questions about the freedom of research versus concerns about the morality of a technology.

  
• 20:10

  Immune cell transdifferentiation: a complex crosstalk between circulating immune cells and the haematopoietic niche

   » ‎ EMBO reports

  Immune cell transdifferentiation: a complex crosstalk between circulating immune cells and the haematopoietic niche

  EMBO Reports 13, 3 (2012). doi:10.1038/embor.2011.238

  Authors: Marie Meister & Dominique Ferrandon

  

• 20:10

  Telomere flip-flop: an unfolding passage to senescence

   » ‎ EMBO reports

  Telomere flip-flop: an unfolding passage to senescence

  EMBO Reports 13, 5 (2012). doi:10.1038/embor.2011.237

  Author: Carolyn M Price

  

• 20:10

  Structural insights into the activation of RIG-I, a nanosensor for viral RNAs

   » ‎ EMBO reports

  Structural insights into the activation of RIG-I, a nanosensor for viral RNAs

  EMBO Reports 13, 7 (2012). doi:10.1038/embor.2011.239

  Authors: Qiu-Xing Jiang & Zhijian J Chen

  EMBO Reports (2011) 12: 11, 1127–1134. doi:10.1038/embor.2011.190Animal cells use a group of innate immune sensors to detect viral invasion. The RIG-I-like receptor (RLR) family of RNA helicases is largely responsible for detecting replicating viral RNAs

  
• 20:10

  Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells

   » ‎ EMBO reports

  Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells

  EMBO Reports 13, 9 (2012). doi:10.1038/embor.2011.241

  Authors: Francesca M Spagnoli, Daniel Besser & Salvador Aznar Benitah

  The international conference ‘Stem Cells in Development and Disease’ took place in September 2011 at the Max-Delbrück-Center for Molecular Medicine (MDC) in Berlin. It brought together scientists working on different types of stem cell and covered the latest findings in stem cell biology, including the genetic and epigenetic mechanisms of reprogramming, maintenance of pluripotency and differentiation.

  
• 20:10

  Stem cell research, scientific freedom and the commodification concern

   » ‎ EMBO reports

  Stem cell research, scientific freedom and the commodification concern

  EMBO Reports 13, 12 (2012). doi:10.1038/embor.2011.232

  Authors: Timothy Caulfield & Ubaka Ogbogu

  For more than a decade, stem cell research has been the topic of often-polarized debates about the nature and scope of scientific freedom (Caulfield, 2004; Downie et al, 2005; Foley, 2000; Hsu, 1999; Keane, 2006; Taylor, 2003).

  
• 20:10

  Is there a neurobiology of the free will?

   » ‎ EMBO reports

  Is there a neurobiology of the free will?

  EMBO Reports 13, 17 (2012). doi:10.1038/embor.2011.229

  Author: Bertram Gerber

  Free will—or rather the question of whether it exists—has been the topic of heated debate among philosophers for millennia. For many neuroscientists too, the idea of freedom poses a dilemma: if what we do is caused by brain processes—which follow the laws of nature—our behaviour

  
• 20:10

  The return of the phage

   » ‎ EMBO reports

  The return of the phage

  EMBO Reports 13, 20 (2012). doi:10.1038/embor.2011.234

  Author: Philip Hunter

  Over the past decade, bacteriophages have occasionally stirred public and media interest because of their potential as biological weapons against bacterial infections. Such reports have tended to come from Russian or Georgian laboratories, whereas Western research institutes and companies have usually found that phages do

  
• 20:10

  When life gets physical

   » ‎ EMBO reports

  When life gets physical

  EMBO Reports 13, 24 (2012). doi:10.1038/embor.2011.236

  Author: Andrea Rinaldi

  The subatomic world is nothing like the world that biologists study. Physicists have struggled for almost a century to understand the wave–particle duality of matter and energy, but many questions remain unanswered. That biological systems ultimately obey the rules of quantum mechanics might be self-evident,

  
• 20:10

  DNA methylation: TET proteins—guardians of CpG islands?

   » ‎ EMBO reports

  DNA methylation: TET proteins—guardians of CpG islands?

  EMBO Reports 13, 28 (2012). doi:10.1038/embor.2011.233

  Authors: Kristine Williams, Jesper Christensen & Kristian Helin

  DNA methylation is involved in key cellular processes, including X-chromosome inactivation, imprinting and transcriptional silencing of specific genes and repetitive elements. DNA methylation patterns are frequently perturbed in human diseases such as imprinting disorders and cancer. The recent discovery that the three members of the

  
• 20:10

  Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

   » ‎ EMBO reports

  Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

  EMBO Reports 13, 36 (2012). doi:10.1038/embor.2011.231

  Authors: Zhiwei Wang, Hiroyuki Inuzuka, Hidefumi Fukushima, Lixin Wan, Daming Gao, Shavali Shaik, Fazlul H Sarkar & Wenyi Wei

  FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins—such as Notch, c-Myc, cyclin E and c-Jun—for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell cycle progression, cell growth, cellular metabolism, differentiation and apoptosis. Loss

  
• 20:10

  Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2

   » ‎ EMBO reports

  Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2

  EMBO Reports 13, 44 (2012). doi:10.1038/embor.2011.221

  Authors: Noriko Hosoya, Miyuki Okajima, Aiko Kinomura, Yoshihiro Fujii, Takashi Hiyama, Jiying Sun, Satoshi Tashiro & Kiyoshi Miyagawa

  The meiosis-specific synaptonemal complex protein SYCP3 has been reported to be aberrantly expressed in tumours. However, in contrast to its well-defined function in meiosis, its possible role in mitotic cells is entirely unknown. Here, we show that SYCP3 is expressed in a range of primary

  
• 20:10

  Five dysfunctional telomeres predict onset of senescence in human cells

   » ‎ EMBO reports

  Five dysfunctional telomeres predict onset of senescence in human cells

  EMBO Reports 13, 52 (2012). doi:10.1038/embor.2011.227

  Authors: Zeenia Kaul, Anthony J Cesare, Lily I Huschtscha, Axel A Neumann & Roger R Reddel

  Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1 proteins, are not associated

  
• 20:10

  A model for mitotic inheritance of histone lysine methylation

   » ‎ EMBO reports

  A model for mitotic inheritance of histone lysine methylation

  EMBO Reports 13, 60 (2012). doi:10.1038/embor.2011.206

  Authors: Mo Xu, Weixiang Wang, She Chen & Bing Zhu

  Histone lysine methylation has been implicated in epigenetic regulation of transcription. Using stable-isotope labelling and quantitative mass spectrometry, we analysed the dynamics of histone lysine methylation. Here we report that histone methylation levels are transiently reduced during S phase and are gradually re-established during subsequent

  
• 20:10

  A new proofreading mechanism for lesion bypass by DNA polymerase-λ

   » ‎ EMBO reports

  A new proofreading mechanism for lesion bypass by DNA polymerase-λ

  EMBO Reports 13, 68 (2012). doi:10.1038/embor.2011.226

  Authors: Emmanuele Crespan, Giovanni Maga & Ulrich Hübscher

  Replicative DNA polymerases (DNA pols) increase their fidelity by removing misincorporated nucleotides with their 3′ → 5′ exonuclease activity. Exonuclease activity reduces translesion synthesis (TLS) efficiency and TLS DNA pols lack 3′ → 5′ exonuclease activity. Here we show that physiological concentrations of pyrophosphate (PP

  
• 20:10

  Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

   » ‎ EMBO reports

  Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

  EMBO Reports 13, 75 (2012). doi:10.1038/embor.2011.211

  Authors: Jan A Kullmann, Alexander Neumeyer, Christine B Gurniak, Eckhard Friauf, Walter Witke & Marco B Rust

  Cerebellar granule neurons (CGNs) exploit Bergmann glia (BG) fibres for radial migration, and cell–cell contacts have a pivotal role in this process. Nevertheless, little is known about the mechanisms that control CGN–BG interaction. Here we demonstrate that the actin-binding protein profilin1 is essential for CGN–glial

  
• 20:10

  Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila

   » ‎ EMBO reports

  Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila

  EMBO Reports 13, 83 (2012). doi:10.1038/embor.2011.223

  Authors: Sergey A Sinenko, Jiwon Shim & Utpal Banerjee

  Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila

  
• 20:10

  Wnts need a p(assport)24 to leave the ER

   » ‎ EMBO reports

  Wnts need a p(assport)24 to leave the ER

  EMBO Reports 13, 90 (2012). doi:10.1038/embor.2011.244

  Author: Lucy Palmer, Jean-Paul Vincent & Karen Beckett

  Correction to:EMBO Rep (2011) 12, 1207–1208. doi:10.1038/embor.2011.222In this article, published online 18 November 2011 and in the December issue, Snx3 was incorrectly labelled as Snx6 in Fig 1. The correct version of the figure appears

  
• 20:10

  More than a blog

   » ‎ EMBO reports

  More than a blog

  EMBO Reports 13, 90 (2012). doi:10.1038/embor.2011.245

  Author: Howard Wolinsky

  Correction to:EMBO Rep (2011) 12, 1102–1105. doi:10.1038/embor.2011.201In this article, published online 14 October 2011 and in the November issue, Daniel MacArthur's name was spelled incorrectly. We apologize to Dr MacArthur for this error.

  
• December 01, 2011
• 19:59

  Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

   » ‎ EMBO reports

  Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

  EMBO Reports 12, 1300 (2011). doi:10.1038/embor.2011.205

  Authors: Paola Lo Surdo, Matthew J Bottomley, Alessandra Calzetta, Ethan C Settembre, Agostino Cirillo, Shilpa Pandit, Yan G Ni, Brian Hubbard, Ayesha Sitlani & Andrea Carfí

  The protein PCSK9 (proprotein convertase subtilisin/kexin type 9) is a key regulator of low-density lipoprotein receptor (LDLR) levels and cardiovascular health. We have determined the crystal structure of LDLR bound to PCSK9 at neutral pH. The structure shows LDLR in a new extended conformation. The

  
• 19:59

  The hitchhiker's guide to E. coli

   » ‎ EMBO reports

  The hitchhiker's guide to E. coli

  EMBO Reports 12, 1205 (2011). doi:10.1038/embor.2011.214

  Author: Howy Jacobs

  Intergalactic bacterial command has intercepted the following distress call from Planet Earth:“We write to alert you to a looming disaster, and to appeal for help. For tens of millions of years we serenely coexisted with the mammalian hosts in whose guts we reside. Not

  
• 19:59

  Algorithms and surrogate markers in translational research

   » ‎ EMBO reports

  Algorithms and surrogate markers in translational research

  EMBO Reports 12, 1206 (2011). doi:10.1038/embor.2011.215

  Author: Paul van Helden

  Most clinicians are familiar with the concept of diagnostic markers. A physician takes a sample—urine, blood, saliva or tissue—and gives it to an analytical laboratory that returns either a positive or negative result that might or might not lead to a diagnosis of disease. In

  
• 19:59

  Wnts need a p(assport)24 to leave the ER

   » ‎ EMBO reports

  Wnts need a p(assport)24 to leave the ER

  EMBO Reports 12, 1207 (2011). doi:10.1038/embor.2011.222

  Authors: Lucy Palmer, Jean-Paul Vincent & Karen Beckett

  Wnt signalling proteins regulate diverse cellular processes during development and homeostasis. Since misregulation of Wnt signalling is associated with cancer, most research has been aimed at characterizing the signal transduction pathway. Recently, attention has focused on Wnt production due to the identification of factors required

  
• 19:59

  Pol II caught speeding by single gene imaging

   » ‎ EMBO reports

  Pol II caught speeding by single gene imaging

  EMBO Reports 12, 1208 (2011). doi:10.1038/embor.2011.217

  Authors: Danielle Cannon & Jonathan R Chubb

  The transcription elongation rate of RNA polymerase II (Pol II) has been re-estimated persistently for more than 30 years using a variety of methods. A new imaging-based estimate of elongation rate on an HIV-derived transgene implies Pol II can elongate at least an order-of-magnitude faster

  
• 19:59

  Protein phosphatases, from molecules to networks

   » ‎ EMBO reports

  Protein phosphatases, from molecules to networks

  EMBO Reports 12, 1211 (2011). doi:10.1038/embor.2011.225

  Author: Anne-Claude Gingras

  The third EMBO-sponsored 'Europhosphatases' meeting brought together 180 participants with a wide range of backgrounds and research interests to discuss the current status of research on phosphatases. It became clear at this meeting that the field is very active, and just as diverse as its members. This report highlights some of the transformative research presented at the meeting.

  
• 19:59

  Protein synthesis and translational control: at eye level with the ribosome

   » ‎ EMBO reports

  Protein synthesis and translational control: at eye level with the ribosome

  EMBO Reports 12, 1214 (2011). doi:10.1038/embor.2011.224

  Authors: Kathrin Leppek, Johanna Schott & Georg Stoecklin

  At the EMBO Conference on ‘Protein Synthesis and Translational Control’ held in Heidelberg in September 2011, scientists shared their latest findings on the structure and function of the ribosome, mRNA-specific regulation of translation and the numerous quality control mechanisms that ensure accurate protein synthesis.

  
• 19:59

  Teaching and textbooks

   » ‎ EMBO reports

  Teaching and textbooks

  EMBO Reports 12, 1217 (2011). doi:10.1038/embor.2011.216

  EMBO reports: How did you become involved in editing and updating Ben Lewin's book?Jocelyn Krebs: I had long been a reviewer for a number of different textbooks and I know a previous editor of Genes, with whom I had been

  
• 19:59

  The ubiquity of consciousness

   » ‎ EMBO reports

  The ubiquity of consciousness

  EMBO Reports 12, 1221 (2011). doi:10.1038/embor.2011.218

  Authors: Anthony J Trewavas & František Baluška

  In his essay, What about ‘information’?, Massimo Pigliucci (2011) makes an eloquent argument to counter the claims of supporters of intelligent design, who argue that the evolution of intelligence must have been guided by some supernatural force. But, in making his case, he

  
• 19:59

  Will we wake up to biodiversity?

   » ‎ EMBO reports

  Will we wake up to biodiversity?

  EMBO Reports 12, 1226 (2011). doi:10.1038/embor.2011.220

  Author: Howard Wolinsky

  The United Nations' (UN) International Year of Biodiversity in 2010 was supposed to see the adoption of measures that would slow global environmental decline and the continuing loss of endangered species and habitats. Even before, in 2002, most UN members had committed to halting the

  
• 19:59

  A new target for personalized medicine

   » ‎ EMBO reports

  A new target for personalized medicine

  EMBO Reports 12, 1229 (2011). doi:10.1038/embor.2011.219

  Author: Philip Hunter

  Interest in epigenetics has taken off over the past few years as molecular biologists have realized the major role it has played in evolution. Indeed, growing evidence that adaptations at the epigenetic level are sometimes passed down to successive generations would explain how species quickly

  
• 19:59

  Superinfection in malaria: Plasmodium shows its iron will

   » ‎ EMBO reports

  Superinfection in malaria: Plasmodium shows its iron will

  EMBO Reports 12, 1233 (2011). doi:10.1038/embor.2011.213

  Authors: Sílvia Portugal, Hal Drakesmith & Maria M Mota

  After the bite of a malaria-infected mosquito, the Plasmodium sporozoite infects liver cells and produces thousands of merozoites, which then infect red blood cells, causing malaria. In malaria-endemic areas, several hundred infected mosquitoes can bite an individual each year, increasing the risk of superinfection.

  
• 19:59

  Mutability of prions

   » ‎ EMBO reports

  Mutability of prions

  EMBO Reports 12, 1243 (2011). doi:10.1038/embor.2011.191

  Authors: Jiali Li, Sukhvir P Mahal, Cheryl A Demczyk & Charles Weissmann

  Murine prions transferred from brain to cultured cells gradually adapt to the new environment. Brain-derived 22L prions can infect neuroblastoma-derived PK1 cells in the presence of swainsonine (swa); that is, they are ‘swa resistant’. PK1 cell-adapted 22L prions are swa sensitive; however, propagation in swa

  
• 19:59

  CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I

   » ‎ EMBO reports

  CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I

  EMBO Reports 12, 1251 (2011). doi:10.1038/embor.2011.209

  Authors: Vasily Rybakin, Jean-Pierre Clamme, Jeanette Ampudia, Pia P Yachi & Nicholas R J Gascoigne

  Bimolecular fluorescence complementation was used to engineer CD8 molecules so that CD8αα and CD8αβ dimers can be independently visualized on the surface of a T cell during antigen recognition. Using this approach, we show that CD8αα is recruited to the immunological synapse almost as well

  
• 19:59

  A proteasome-dependent, TAP-independent pathway for cross-presentation of phagocytosed antigen

   » ‎ EMBO reports

  A proteasome-dependent, TAP-independent pathway for cross-presentation of phagocytosed antigen

  EMBO Reports 12, 1257 (2011). doi:10.1038/embor.2011.203

  Authors: Nawel Merzougui, Roland Kratzer, Loredana Saveanu & Peter van Endert

  Major histocompatibility complex (MHC) class I cross-presentation is thought to involve two pathways, one of which depends on both the TAP transporters and the proteasome and the other on neither. We found that preincubation of TAP-deficient dendritic cells at low temperature increases the density of

  
• 19:59

  p24 proteins are required for secretion of Wnt ligands

   » ‎ EMBO reports

  p24 proteins are required for secretion of Wnt ligands

  EMBO Reports 12, 1265 (2011). doi:10.1038/embor.2011.212

  Authors: Tina Buechling, Varun Chaudhary, Kerstin Spirohn, Matthias Weiss & Michael Boutros

  During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila

  
• 19:59

  Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

   » ‎ EMBO reports

  Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

  EMBO Reports 12, 1273 (2011). doi:10.1038/embor.2011.210

  Authors: Arjan Kortholt, Rama Kataria, Ineke Keizer-Gunnink, Wouter N Van Egmond, Ankita Khanna & Peter J M Van Haastert

  Central to chemotaxis is the molecular mechanism by which cells exhibit directed movement in shallow gradients of a chemoattractant. We used Dictyostelium mutants to investigate the minimal requirements for chemotaxis, and identified a basal signalling module providing activation of Ras at the leading edge,

  
• 19:59

  Fast transcription rates of RNA polymerase II in human cells

   » ‎ EMBO reports

  Fast transcription rates of RNA polymerase II in human cells

  EMBO Reports 12, 1280 (2011). doi:10.1038/embor.2011.196

  Authors: Paolo Maiuri, Anna Knezevich, Alex De Marco, Davide Mazza, Anna Kula, Jim G McNally & Alessandro Marcello

  Averaged estimates of RNA polymerase II (RNAPII) elongation rates in mammalian cells have been shown to range between 1.3 and 4.3 kb min−1. In this work, nascent RNAs from an integrated human immunodeficiency virus type 1-derived vector were detectable at the single living

  
• 19:59

  Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase

   » ‎ EMBO reports

  Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase

  EMBO Reports 12, 1286 (2011). doi:10.1038/embor.2011.189

  Authors: Suraj Adhikary & Brandt F Eichman

  DNA glycosylases specialized for the repair of alkylation damage must identify, with fine specificity, a diverse array of subtle modifications within DNA. The current mechanism involves damage sensing through interrogation of the DNA duplex, followed by more specific recognition of the target base inside the

  
• 19:59

  AMIGO is an auxiliary subunit of the Kv2.1 potassium channel

   » ‎ EMBO reports

  AMIGO is an auxiliary subunit of the Kv2.1 potassium channel

  EMBO Reports 12, 1293 (2011). doi:10.1038/embor.2011.204

  Authors: Marjaana A Peltola, Juha Kuja-Panula, Sari E Lauri, Tomi Taira & Heikki Rauvala

  Kv2.1 is a potassium channel α-subunit abundantly expressed throughout the brain. It is a main component of delayed rectifier current (IK) in several neuronal types and a regulator of excitability during high-frequency firing. Here we identify AMIGO (amphoterin-induced gene and ORF), a

  
• October 29, 2011
• 9:15

  Liberty, safety or neither?

   » ‎ EMBO reports

  Liberty, safety or neither?

  EMBO Reports 12, 1085 (2011). doi:10.1038/embor.2011.198

  Author: Howy Jacobs

  
• 9:15

  A Faustian bargain?

   » ‎ EMBO reports

  A Faustian bargain?

  EMBO Reports 12, 1086 (2011). doi:10.1038/embor.2011.197

  Author: Steven Rose

  
• 9:15

  Endothelial laminins underlie the tip cell microenvironment

   » ‎ EMBO reports

  Endothelial laminins underlie the tip cell microenvironment

  EMBO Reports 12, 1087 (2011). doi:10.1038/embor.2011.202

  Author: Jan Kitajewski

  
• 9:15

  Natural immunity

   » ‎ EMBO reports

  Natural immunity

  EMBO Reports 12, 1089 (2011). doi:10.1038/embor.2011.195

  Authors: Leena von Hertzen, Ilkka Hanski & Tari Haahtela

  
• 9:15

  Tasty and healthy TR(i)Ps

   » ‎ EMBO reports

  Tasty and healthy TR(i)Ps

  EMBO Reports 12, 1094 (2011). doi:10.1038/embor.2011.200

  Authors: Bernd Nilius & Giovanni Appendino

  
• 9:15

  More than a blog

   » ‎ EMBO reports

  More than a blog

  EMBO Reports 12, 1102 (2011). doi:10.1038/embor.2011.201

  Author: Howard Wolinsky

  
• 9:15

  Total recall

   » ‎ EMBO reports

  Total recall

  EMBO Reports 12, 1106 (2011). doi:10.1038/embor.2011.199

  Author: Philip Hunter

  
• 9:15

  Prions on the move

   » ‎ EMBO reports

  Prions on the move

  EMBO Reports 12, 1109 (2011). doi:10.1038/embor.2011.192

  Authors: Charles Weissmann, Jiali Li, Sukhvir P. Mahal & Shawn Browning

  
• 9:15

  The emerging functions of septins in metazoans

   » ‎ EMBO reports

  The emerging functions of septins in metazoans

  EMBO Reports 12, 1118 (2011). doi:10.1038/embor.2011.193

  Authors: Juha Saarikangas & Yves Barral

  
• 9:15

  The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

   » ‎ EMBO reports

  The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

  EMBO Reports 12, 1127 (2011). doi:10.1038/embor.2011.190

  Authors: Filiz Civril, Matthew Bennett, Manuela Moldt, Tobias Deimling, Gregor Witte, Stefan Schiesser, Thomas Carell & Karl-Peter Hopfner

  
• 9:15

  Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

   » ‎ EMBO reports

  Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

  EMBO Reports 12, 1135 (2011). doi:10.1038/embor.2011.194

  Authors: Denise Stenzel, Claudio A Franco, Soline Estrach, Amel Mettouchi, Dominique Sauvaget, Ian Rosewell, Andreas Schertel, Hannah Armer, Anna Domogatskaya, Sergey Rodin, Karl Tryggvason, Lucy Collinson, Lydia Sorokin & Holger Gerhardt

  
• 9:15

  A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

   » ‎ EMBO reports

  A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

  EMBO Reports 12, 1144 (2011). doi:10.1038/embor.2011.165

  Authors: Fillip Port, George Hausmann & Konrad Basler

  
• 9:15

  miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2

   » ‎ EMBO reports

  miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2

  EMBO Reports 12, 1153 (2011). doi:10.1038/embor.2011.176

  Authors: Nils Pfaff, Jan Fiedler, Angelika Holzmann, Axel Schambach, Thomas Moritz, Tobias Cantz & Thomas Thum

  
• 9:15

  Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

   » ‎ EMBO reports

  Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

  EMBO Reports 12, 1160 (2011). doi:10.1038/embor.2011.184

  Authors: Weixiang Wang, Zhi Chen, Zhuo Mao, Huihui Zhang, Xiaojun Ding, She Chen, Xiaodong Zhang, Ruiming Xu & Bing Zhu

  
• 9:15

  A genetic in vivo system to detect asymmetrically distributed RNA

   » ‎ EMBO reports

  A genetic in vivo system to detect asymmetrically distributed RNA

  EMBO Reports 12, 1167 (2011). doi:10.1038/embor.2011.178

  Authors: N JayaNandanan, Elizabeth R Gavis, Veit Riechmann & Maria Leptin

  
• 9:15

  PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3

   » ‎ EMBO reports

  PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3

  EMBO Reports 12, 1175 (2011). doi:10.1038/embor.2011.174

  Authors: Fangyan Dai, Tao Shen, Zhaoyong Li, Xia Lin & Xin-Hua Feng

  
• 9:15

  Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57

   » ‎ EMBO reports

  Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57

  EMBO Reports 12, 1182 (2011). doi:10.1038/embor.2011.173

  Authors: Daniel Prins, Jody Groenendyk, Nicolas Touret & Marek Michalak

  
• 9:15

  Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast

   » ‎ EMBO reports

  Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast

  EMBO Reports 12, 1189 (2011). doi:10.1038/embor.2011.188

  Authors: Ayano Kagami, Takeshi Sakuno, Yuya Yamagishi, Tadashi Ishiguro, Tatsuya Tsukahara, Katsuhiko Shirahige, Koichi Tanaka & Yoshinori Watanabe

  
• 9:15

  Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands

   » ‎ EMBO reports

  Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands

  EMBO Reports 12, 1196 (2011). doi:10.1038/embor.2011.177

  Authors: Lei Liu, Sukanya Narasimhan, Jianfeng Dai, Lili Zhang, Gong Cheng & Erol Fikrig

  
• 9:15

  Ribosome degradation in growing bacteria

   » ‎ EMBO reports

  Ribosome degradation in growing bacteria

  EMBO Reports 12, 1204 (2011). doi:10.1038/embor.2011.105

  Authors: Kerli Piir, Anton Paier, Aivar Liiv, Tanel Tenson & Ülo Maiväli

  
• 9:15

  Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

   » ‎ EMBO reports

  Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

  EMBO Reports 12, 1204 (2011). doi:10.1038/embor.2011.207

  Authors: Pavel Plevka, Anthony J. Battisti, Jiraphan Junjhon, Dennis C. Winkler, Heather A. Holdaway, Ponsook Keelapang, Nopporn Sittisombut, Richard J. Kuhn, Alasdair C. Steven & Michael G. Rossmann

  
• 9:15

  PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3

   » ‎ EMBO reports

  PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3

  EMBO Reports 12, 1204 (2011). doi:10.1038/embor.2011.208

  Authors: Fangyan Dai, Tao Shen, Zhaoyong Li, Xia Lin & Xin-Hua Feng

  
• September 30, 2011
• 23:48

  The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators

   » ‎ EMBO reports

  The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators

  EMBO Reports 12, 1018 (2011). doi:10.1038/embor.2011.152

  Authors: Pablo García-Gutiérrez, Francisco Juárez-Vicente, Francisco Gallardo-Chamizo, Patrick Charnay & Mario García-Domínguez

  
• 23:48

  The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits

   » ‎ EMBO reports

  The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits

  EMBO Reports 12, 1024 (2011). doi:10.1038/embor.2011.155

  Authors: Alexandra Hackmann, Thomas Gross, Claudia Baierlein & Heike Krebber

  
• 23:48

  Lac operator repeats generate a traceable fragile site in mammalian cells

   » ‎ EMBO reports

  Lac operator repeats generate a traceable fragile site in mammalian cells

  EMBO Reports 12, 1032 (2011). doi:10.1038/embor.2011.158

  Authors: Ariana Jacome & Oscar Fernandez-Capetillo

  
• 23:48

  Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels

   » ‎ EMBO reports

  Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels

  EMBO Reports 12, 1039 (2011). doi:10.1038/embor.2011.153

  Authors: Joachim G Schulz, Helga Ceulemans, Emmanuel Caussinus, Maria F Baietti, Markus Affolter, Bassem A Hassan & Guido David

  
• 23:48

  Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye

   » ‎ EMBO reports

  Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye

  EMBO Reports 12, 1047 (2011). doi:10.1038/embor.2011.159

  Authors: Emily R Olson, Raluca Pancratov, Sujash S Chatterjee, Binita Changkakoty, Zeeshan Pervaiz & Ramanuj DasGupta

  
• 23:48

  LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

   » ‎ EMBO reports

  LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

  EMBO Reports 12, 1055 (2011). doi:10.1038/embor.2011.175

  Authors: Andrei Glinka, Christine Dolde, Nadine Kirsch, Ya-Lin Huang, Olga Kazanskaya, Dierk Ingelfinger, Michael Boutros, Cristina-Maria Cruciat & Christof Niehrs

  
• 23:48

  Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

   » ‎ EMBO reports

  Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

  EMBO Reports 12, 1062 (2011). doi:10.1038/embor.2011.154

  Authors: Alexandre Vendrell, Mar Martínez-Pastor, Alberto González-Novo, Amparo Pascual-Ahuir, David A Sinclair, Markus Proft & Francesc Posas

  
• 23:48

  CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

   » ‎ EMBO reports

  CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

  EMBO Reports 12, 1069 (2011). doi:10.1038/embor.2011.151

  Authors: Lilia G Noriega, Jérôme N Feige, Carles Canto, Hiroyasu Yamamoto, Jiujiu Yu, Mark A Herman, Chikage Mataki, Barbara B Kahn & Johan Auwerx

  
• 23:48

  Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

   » ‎ EMBO reports

  Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

  EMBO Reports 12, 1077 (2011). doi:10.1038/embor.2011.149

  Authors: Martin Mikl, Georgia Vendra & Michael A Kiebler

  
• 23:48

  The cost of living longer

   » ‎ EMBO reports

  The cost of living longer

  EMBO Reports 12, 1000 (2011). doi:10.1038/embor.2011.183

  Author: Philip Hunter

  
• 23:48

  The interplay between morphogens and tissue growth

   » ‎ EMBO reports

  The interplay between morphogens and tissue growth

  EMBO Reports 12, 1003 (2011). doi:10.1038/embor.2011.172

  Authors: Andrés Dekanty & Marco Milán

  
• 23:48

  Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

   » ‎ EMBO reports

  Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

  EMBO Reports 12, 1011 (2011). doi:10.1038/embor.2011.171

  Authors: Masayuki Yamasaki, Timothy J Sendall, Mary C Pearce, James C Whisstock & James A Huntington

  
• 23:48

  These are your rights

   » ‎ EMBO reports

  These are your rights

  EMBO Reports 12, 981 (2011). doi:10.1038/embor.2011.180

  Author: Howy Jacobs

  
• 23:48

  Unended knights' tournaments

   » ‎ EMBO reports

  Unended knights' tournaments

  EMBO Reports 12, 982 (2011). doi:10.1038/embor.2011.181

  Author: Ladislav Kováč

  
• 23:48

  The structural diversity in α1-antitrypsin misfolding

   » ‎ EMBO reports

  The structural diversity in α1-antitrypsin misfolding

  EMBO Reports 12, 983 (2011). doi:10.1038/embor.2011.187

  Author: Stephen P Bottomley

  
• 23:48

  Metabolic signals regulate SIRT1 expression

   » ‎ EMBO reports

  Metabolic signals regulate SIRT1 expression

  EMBO Reports 12, 985 (2011). doi:10.1038/embor.2011.179

  Authors: Angeliki Chalkiadaki & Leonard Guarente

  
• 23:48

  Lineage commitments: emphasis on embryonic–extraembryonic interfaces

   » ‎ EMBO reports

  Lineage commitments: emphasis on embryonic–extraembryonic interfaces

  EMBO Reports 12, 987 (2011). doi:10.1038/embor.2011.186

  Author: Karen M Downs

  The EMBO Workshop on ‘Lineage Commitments: Emphasis on Embryonic–Extraembryonic Interfaces’, held in May 2011, demonstrated that embryonic and extraembryonic tissues play early and significant interacting roles that mutually promote each other's further and correct deployment within the mammalian conceptus. Highlighted here are those presentations that directly addressed embryonic–extraembryonic interfaces in building the mammalian fetus.

  
• 23:48

  Of mice and men

   » ‎ EMBO reports

  Of mice and men

  EMBO Reports 12, 991 (2011). doi:10.1038/embor.2011.185

  Authors: Thomas C Erren, J Valérie Groß, Melissa S Koch & V Benno Meyer-Rochow

  
• 23:48

  Stem-cell tourism and scientific responsibility

   » ‎ EMBO reports

  Stem-cell tourism and scientific responsibility

  EMBO Reports 12, 992 (2011). doi:10.1038/embor.2011.156

  Authors: Zubin Master & David B Resnik

  
• 23:48

  Dismay with GM maize

   » ‎ EMBO reports

  Dismay with GM maize

  EMBO Reports 12, 996 (2011). doi:10.1038/embor.2011.182

  Author: Gerhart U Ryffel

  
• September 01, 2011
• 7:57

  Adaptation, redundancy or resilience

   » ‎ EMBO reports

  Adaptation, redundancy or resilience

  EMBO Reports 12, 872 (2011). doi:10.1038/embor.2011.162

  Author: Paul van Helden

  The study of the natural environment teaches us that ecological systems rich in biodiversity have greater resilience than less diverse systems, and that resource-poor ecosystems tend to have greater biodiversity to buffer against environmental change. The African savannah, a huge ecosystem, contains an abundance of

  
• 7:57

  The incredible shrinking organelle

   » ‎ EMBO reports

  The incredible shrinking organelle

  EMBO Reports 12, 873 (2011). doi:10.1038/embor.2011.168

  Author: Michael W Gray

  Considering its central role in energy metabolism in almost all eukaryotes, the mitochondrion is an amazingly plastic organelle, both evolutionarily and functionally. The few genes that the mitochondrial genome (mitochondrial DNA; mtDNA) encodes are clearly bacterial in origin—emanating from the α-proteobacterial lineage—supporting the widely held

  
• 7:57

  A feast for the senses: development and function of sensory systems

   » ‎ EMBO reports

  A feast for the senses: development and function of sensory systems

  EMBO Reports 12, 874 (2011). doi:10.1038/embor.2011.170

  Authors: Andrea Streit & David W Raible

  The EMBO Workshop ‘Frontiers in Sensory Development’ took place in May 2011 in Barcelona. The meeting brought together a diverse group of scientists to tackle the formation and function of the sensory nervous system in all its complexity. The discussions ranged from how signalling and transcriptional networks control cell identity, architecture and behaviour, to how connectivity is established and how such networks have evolved to generate functional diversity.