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Molecular Cell
Xueliang Gao, Haizhen Wang, Jenny J. Yang, Xiaowei Liu, Zhi-Ren Liu. Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. We report here that PKM2 locali....
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Molecular Cell
Alison J. Hanson, Heather A. Wallace, Tanner J. Freeman, R. Daniel Beauchamp, Laura A. Lee, Ethan Lee. A key event in Wnt signaling is conversion of TCF/Lef from a transcriptional repressor to an activator, yet how this switch occurs is not well understood. Here, we report an unanticipated role for....
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Molecular Cell
Laura A. Simmons Kovacs, Michael B. Mayhew, David A. Orlando, Yuanjie Jin, Qingyun Li, Chenchen Huang, Steven I. Reed, Sayan Mukherjee, Steven B. Haase. During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex....
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Molecular Cell
Kannanganattu V. Prasanth. In this issue of Molecular Cell,Audas et al. (2012) demonstrate that a class of stress-induced noncoding RNAs immobilizes proteins in the nucleolus in response to a specific stimulus.
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Molecular Cell
Roshan M. Kumar, James J. Collins. Cells can make fate decisions in response to information from the environment. In this issue of Molecular Cell, Chen et al. (2012) describe how the design of a signal-processing pathway all....
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Molecular Cell
Eva Madi Riising, Kristian Helin. In this issue, Mousavi et al. (2011) report a novel gene activation function of the H3K27 methyltransferase, Ezh1, in addition to its known role in transcriptional repression.
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Molecular Cell
Timothy E. Audas, Mathieu D. Jacob, Stephen Lee. Cellular pathways are established and maintained by stochastic interactions of highly mobile molecules. The nucleolus plays a central role in the regulation of these molecular networks by capturin....
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Molecular Cell
Alain R. Bataille, Célia Jeronimo, Pierre-Étienne Jacques, Louise Laramée, Marie-Ève Fortin, Audrey Forest, Maxime Bergeron, Steven D. Hanes, François Robert. Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple repeats of the ....
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Molecular Cell
Thang Van Nguyen, Pornpimon Angkasekwinai, Hong Dou, Feng-Ming Lin, Long-Sheng Lu, Jinke Cheng, Y. Eugene Chin, Chen Dong, Edward T.H. Yeh. Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the de....
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Molecular Cell
Lior Golomb, Debora Rosa Bublik, Sylvia Wilder, Reinat Nevo, Vladimir Kiss, Kristina Grabusic, Sinisa Volarevic, Moshe Oren. Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required for ribosome biogenesis. We report that transcription of the β-kary....
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Molecular Cell
Armin M. Gamper, Xinxian Qiao, Jennifer Kim, Liyong Zhang, Michelle C. DeSimone, W. Kimryn Rathmell, Yong Wan. The transcription factor Krüppel-like factor 4 (KLF4) is an important regulator of cell-fate decision, including cell-cycle regulation, apoptosis, and stem cell renewal, and plays an ambivalent ro....
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Molecular Cell
Purusharth Rajyaguru, Meipei She, Roy Parker. The formation of mRNPs controls the interaction of the translation and degradation machinery with individual mRNAs. The yeast Scd6 protein and its orthologs regulate translation and mRNA degradati....
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Molecular Cell
Catherine A. Cremona, Prabha Sarangi, Yan Yang, Lisa E. Hang, Sadia Rahman, Xiaolan Zhao. The cellular response to DNA damage employs multiple dynamic protein modifications to exert rapid and adaptable effects. Substantial work has detailed the roles of canonical checkpoint-mediated ph....
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Molecular Cell
Jennifer A. Fairley, Louise E. Mitchell, Tracy Berg, Niall S. Kenneth, Conrad von Schubert, Herman H.W. Silljé, René H. Medema, Erich A. Nigg, Robert J. White. Polo-like kinase Plk1 controls numerous aspects of cell-cycle progression. We show that it associates with tRNA and 5S rRNA genes and regulates their transcription by RNA polymerase III (pol III) ....
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Molecular Cell
Karin Öjemalm, Katrin K. Halling, IngMarie Nilsson, Gunnar von Heijne. α-helical integral membrane proteins critically depend on the correct insertion of their transmembrane α helices into the lipid bilayer for proper folding, yet a surprisingly large fraction of the....
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Molecular Cell
Woo Jae Kim, Miguel N. Rivera, Erik J. Coffman, Daniel A. Haber. WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in β-catenin turnover, but its effect on n....
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Molecular Cell
Stacie L. Bumgarner, Gregor Neuert, Benjamin F. Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R. Fink. Mechanisms through which long intergenic noncoding RNAs (ncRNAs) exert regulatory effects on eukaryotic biological processes remain largely elusive. Most studies of these phenomena rely on methods....
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Molecular Cell
Monika S. Kowalczyk, Jim R. Hughes, David Garrick, Magnus D. Lynch, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Simon J. McGowan, Marco De Gobbi, Mona Hosseini, Douglas Vernimmen, Jill M. Brown, Nicola E. Gray, Licio Collavin, Richard J. Gibbons, Jonathan Flint, Stephen Taylor, Veronica J. Buckle, Thomas A. Milne, William G. Wood, Douglas R. Higgs. A substantial amount of organismal complexity is thought to be encoded by enhancers which specify the location, timing, and levels of gene expression. In mammals there are more enhancers than prom....
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Molecular Cell
Yan Huang, Wencheng Li, Xiao Yao, Qi-jiang Lin, Jing-wen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, Gang Wang. Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its MED23 subunit. Combining tandem affinity purificatio....
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Molecular Cell
Neil D. Perkins. The importance of parallel signaling pathways controlling NF-κB subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that RelA (p65) sulfhydration, at its highl....
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Molecular Cell
Joaquín M. Espinosa. In this issue of Molecular Cell, papers by the Price and Roeder labs reveal how the Gdown1 protein antagonizes the general transcription factor TFIIF during RNAPII initiation and elongation....
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Molecular Cell
Hocine W. Mankouri, Wai Kit Chu, Ian D. Hickson. In this issue, Moldovan et al. (2012) report the identification of PARI, a putative human ortholog of the yeast Srs2 protein, which potentially regulates homologous recombination repair via its ab....
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Molecular Cell
Aaron M. Robitaille, Michael N. Hall. In the December 23rd issue of Molecular Cell, Banko et al. (2011) describe a chemical genetic screen that identified 28 novel AMPKα2 direct substrates. A subset of these substrates comprise....
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Molecular Cell
Lily C. Chao, Peter Tontonoz. SIRT1 is a phylogenetically conserved energy sensor. The molecular mechanisms that regulate its catalytic activity, however, are incompletely understood. Gerhart-Hines et al. (2011) have identifie....
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Molecular Cell
Nilkantha Sen, Bindu D. Paul, Moataz M. Gadalla, Asif K. Mustafa, Tanusree Sen, Risheng Xu, Seyun Kim, Solomon H. Snyder. Nuclear factor κB (NF-κB) is an antiapoptotic transcription factor. We show that the antiapoptotic actions of NF-κB are mediated by hydrogen sulfide (H2S) synthesized by cystathionine g....
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Molecular Cell
Weimin Li, Rakesh S. Laishram, Zhe Ji, Christy A. Barlow, Bin Tian, Richard A. Anderson. BIK protein is an initiator of mitochondrial apoptosis, and BIK expression is induced by proapoptotic signals, including DNA damage. Here, we demonstrate that 3′ end processing and expressi....
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Molecular Cell
Bo Cheng, Tiandao Li, Peter B. Rahl, Todd E. Adamson, Nicholas B. Loudas, Jiannan Guo, Katayoun Varzavand, Jeffrey J. Cooper, Xiaopeng Hu, Averell Gnatt, Richard A. Young, David H. Price. Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. We present evidence that Gdown1, ....
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Molecular Cell
Miki Jishage, Sohail Malik, Ulrich Wagner, Beatrix Uberheide, Yasushi Ishihama, Xiaopeng Hu, Brian T. Chait, Averell Gnatt, Bing Ren, Robert G. Roeder. Pol II(G) is a distinct form of RNA polymerase II that contains the tightly associated Gdown1 polypeptide (encoded by POLR2M). Unlike Pol II, Pol II(G) is highly dependent upon Mediator for....
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Molecular Cell
Joshua J. Gruber, Scott H. Olejniczak, Jeongsik Yong, Gaspare La Rocca, Gideon Dreyfuss, Craig B. Thompson. Ars2 is a component of the nuclear cap-binding complex that contributes to microRNA biogenesis and is required for cellular proliferation. Here, we expand on the repertoire of Ars2-dependent micro....
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Molecular Cell
Federico Lazzaro, Daniele Novarina, Flavio Amara, Danielle L. Watt, Jana E. Stone, Vincenzo Costanzo, Peter M. Burgers, Thomas A. Kunkel, Paolo Plevani, Marco Muzi-Falconi. The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replicatio....
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Molecular Cell
Adeline Vitaliano-Prunier, Anna Babour, Lucas Hérissant, Luciano Apponi, Thanasis Margaritis, Frank C.P. Holstege, Anita H. Corbett, Carole Gwizdek, Catherine Dargemont. Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquit....
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Molecular Cell
Alison M. Day, Jonathon D. Brown, Sarah R. Taylor, Jonathan D. Rand, Brian A. Morgan, Elizabeth A. Veal. Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes whose thioredoxin peroxidase activity plays an important role in protecting against oxidative stress, aging, and cancer. Para....
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Molecular Cell
Caryn R. Hale, Sonali Majumdar, Joshua Elmore, Neil Pfister, Mark Compton, Sara Olson, Alissa M. Resch, Claiborne V.C. Glover, Brenton R. Graveley, Rebecca M. Terns, Michael P. Terns. Small RNAs target invaders for silencing in the CRISPR-Cas pathways that protect bacteria and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence elements acquired from in....
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Molecular Cell
Sarah Geisler, Lisa Lojek, Ahmad M. Khalil, Kristian E. Baker, Jeff Coller. Decapping represents a critical control point in regulating expression of protein coding genes. Here, we demonstrate that decapping also modulates expression of long noncoding RNAs (lncRNAs). Spec....
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Molecular Cell
Jing Zhang, Christophe Rouillon, Melina Kerou, Judith Reeks, Kim Brugger, Shirley Graham, Julia Reimann, Giuseppe Cannone, Huanting Liu, Sonja-Verena Albers, James H. Naismith, Laura Spagnolo, Malcolm F. White. The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invadi....
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Molecular Cell
Jia-Yun Chen, Jia-Ren Lin, Karlene A. Cimprich, Tobias Meyer. Growth factors activate Ras, PI3K, and other signaling pathways. It is not well understood how these signals are translated by individual cells into a decision to proliferate or differentiate. Her....
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Molecular Cell
Weiguo Zhang, Serafin U. Colmenares, Gary H. Karpen. Centromeres are essential chromosomal regions required for kinetochore assembly and chromosome segregation. The composition and organization of centromeric nucleosomes containing the essential his....
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Molecular Cell
Aseem Z. Ansari, Marsha Rich Rosner, Julius Adler.
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Molecular Cell
Triona Ni Chonghaile, Anthony Letai. Much deliberation surrounds how the two homeostatic pathways, autophagy and apoptosis, converge; in the December 9 issue of Molecular Cell, Rubinstein et al. (2011) identify a proapoptotic ....
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Molecular Cell
Almut Schulze, Julian Downward. In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1.
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Molecular Cell
Catherine J. Potenski, Hannah L. Klein. RNA:DNA hybrids in the genome are constantly being generated as a by-product of transcription; in this issue, two papers, from Helmrich et al. (2011) and Wahba et al. (2011), provide insight into ....
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Molecular Cell
Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski, Alexander S. Banks, Ji-Hong Lim, Helen Chim, Steven P. Gygi, Pere Puigserver. The NAD+-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as ....
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Molecular Cell
Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Georgia Z. Chen, Titus J. Boggon, Sagar Lonial, Haian Fu, Fadlo R. Khuri, Sumin Kang, Jing Chen. Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to promote such a metabolic switch by, i....
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Molecular Cell
David Matallanas, David Romano, Fahd Al-Mulla, Eric O'Neill, Waleed Al-Ali, Piero Crespo, Brendan Doyle, Colin Nixon, Owen Sansom, Matthias Drosten, Mariano Barbacid, Walter Kolch. K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. Here, we show that mutant K-Ras directly binds to the tumor suppressor RASS....
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Molecular Cell
Robert J. Tomko, Mark Hochstrasser. The 26S proteasome, the central eukaryotic protease, comprises a core particle capped by a 19S regulatory particle (RP). The RP is divisible into base and lid subcomplexes. Lid biogenesis and inco....
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Molecular Cell
Adam J.L. Cook, Zachary A. Gurard-Levin, Isabelle Vassias, Geneviève Almouzni. Proper genome packaging requires coordination of both DNA and histone metabolism. While histone gene transcription and RNA processing adequately provide for scheduled needs, how histone supply adj....
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Molecular Cell
Dominique Ray-Gallet, Adam Woolfe, Isabelle Vassias, Céline Pellentz, Nicolas Lacoste, Aastha Puri, David C. Schultz, Nikolay A. Pchelintsev, Peter D. Adams, Lars E.T. Jansen, Geneviève Almouzni. Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA ....
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Molecular Cell
Peter S. Brzovic, Clemens C. Heikaus, Leonid Kisselev, Robert Vernon, Eric Herbig, Derek Pacheco, Linda Warfield, Peter Littlefield, David Baker, Rachel E. Klevit, Steven Hahn. The structural basis for binding of the acidic transcription activator Gcn4 and one activator-binding domain of the Mediator subunit Gal11/Med15 was examined by NMR. Gal11 activator-binding domain....
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Molecular Cell
Edwin R. Smith, Chengqi Lin, Alexander S. Garrett, Janet Thornton, Nima Mohaghegh, Deqing Hu, Jessica Jackson, Anita Saraf, Selene K. Swanson, Christopher Seidel, Laurence Florens, Michael P. Washburn, Joel C. Eissenberg, Ali Shilatifard. Eleven-nineteen lysine-rich leukemia (ELL) participates in the super elongation complex (SEC) with the RNA polymerase II (Pol II) CTD kinase P-TEFb. SEC is a key regulator in the expression of ....
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Molecular Cell
Anne Helmrich, Monica Ballarino, Laszlo Tora. We show that the time required to transcribe human genes larger than 800 kb spans more than one complete cell cycle, while their transcription speed equals that of smaller genes. Independently of ....
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Molecular Cell
Lamia Wahba, Jeremy D. Amon, Douglas Koshland, Milena Vuica-Ross. Genome instability, a hallmark of cancer progression, is thought to arise through DNA double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs and instability can occ....
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Molecular Cell
Guy Duval-Valentin, Michael Chandler. Transposable elements are important in genome dynamics and evolution. Bacterial insertion sequences (IS) constitute a major group in number and impact. Understanding their role in shaping genomes ....
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Molecular Cell
Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B. Dodd, Corine Mas-Droux, David Barford. The posttranslational modification of C-terminal CAAX motifs in proteins such as Ras, most Rho GTPases, and G protein γ subunits, plays an essential role in determining their subcellular localizat....
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Molecular Cell
Yuezhou Chen, Zhenxiao Yang, Min Meng, Yue Zhao, Na Dong, Hongming Yan, Liping Liu, Mingxiao Ding, H. Benjamin Peng, Feng Shao.
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17:00
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Molecular Cell
Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, Phillip D. Zamore.
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Molecular Cell
Mo Liu, Dung-Fang Lee, Chun-Te Chen, Chia-Jui Yen, Long-Yuan Li, Hong-Jen Lee, Chun-Ju Chang, Wei-Chao Chang, Jung-Mao Hsu, Hsu-Ping Kuo, Weiya Xia, Yongkun Wei, Pei-Chun Chiu, Chao-Kai Chou, Yi Du, Debanjan Dhar, Michael Karin, Chung-Hsuan Chen, Mien-Chie Hung. Proinflammatory cytokine TNFα plays critical roles in promoting malignant cell proliferation, angiogenesis, and tumor metastasis in many cancers. However, the mechanism of TNFα-mediated tumor deve....
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Molecular Cell
Kambiz Mousavi, Hossein Zare, A. Hongjun Wang, Vittorio Sartorelli. Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), trigger....
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Molecular Cell
Akiko Takahashi, Yoshinori Imai, Kimi Yamakoshi, Shinji Kuninaka, Naoko Ohtani, Shin Yoshimoto, Satoshi Hori, Makoto Tachibana, Emma Anderton, Takashi Takeuchi, Yoichi Shinkai, Gordon Peters, Hideyuki Saya, Eiji Hara. Both the DNA damage response (DDR) and epigenetic mechanisms play key roles in the implementation of senescent phenotypes, but very little is known about how these two mechanisms are integrated to....
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Molecular Cell
Steven J. Petesch, John T. Lis. Eukaryotic cells possess many transcriptionally regulated mechanisms to alleviate the nucleosome barrier. Dramatic changes to the chromatin structure of Drosophila melanogaster Hsp70 gene l....
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Molecular Cell
Isaac Edery. In this issue of Molecular Cell, Sancar et al. (2011) show that a morning-induced transcriptional repressor with a phosphorylation-gated half-life is a key cog in driving evening gene expre....
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Molecular Cell
Luying Jia, Hongtao Yu. Cdh1 is a well-established activator of APC/C, a RING-type ubiquitin ligase. In this issue of Molecular Cell, Wan et al. (2011) report an APC/C-independent role of Cdh1 during development a....
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Molecular Cell
Alexandra Seguin, Diane McVey Ward, Jerry Kaplan. In this issue of Molecular Cell, Sanvisens et al. (2011) report a new mechanism for regulation of yeast ribonucleotide reductase activity that occurs during iron deprivation.
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Molecular Cell
S. Hocine, R.H. Singer. Using the MS2 system for labeling mRNA, in this issue, Gallardo et al. (2011) find that telomere lengthening depends on a stable accumulation of multiple telomerase complexes in late S phase and t....
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Molecular Cell
Gencer Sancar, Cigdem Sancar, Britta Brügger, Nati Ha, Timo Sachsenheimer, Elan Gin, Simon Wdowik, Ingrid Lohmann, Felix Wieland, Thomas Höfer, Axel Diernfellner, Michael Brunner. The white-collar complex (WCC), the core transcription factor of the circadian clock of Neurospora, activates morning-specific expression of the transcription repressor CSP1. Newly synthesi....
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Molecular Cell
Assaf D. Rubinstein, Miriam Eisenstein, Yaara Ber, Shani Bialik, Adi Kimchi. Autophagy and apoptosis constitute important determinants of cell fate and engage in a complex interplay in both physiological and pathological settings. The molecular basis of this crosstalk is p....
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Molecular Cell
Gianluca Varetti, Claudia Guida, Stefano Santaguida, Elena Chiroli, Andrea Musacchio. The spindle assembly checkpoint (SAC) restricts mitotic exit to cells that have completed chromosome-microtubule attachment. Cdc20 is a bifunctional protein. In complex with SAC proteins Mad2, Bub....
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Molecular Cell
Lixin Wan, Weiguo Zou, Daming Gao, Hiroyuki Inuzuka, Hidefumi Fukushima, Anders H. Berg, Rebecca Drapp, Shavali Shaik, Dorothy Hu, Chantel Lester, Manuel Eguren, Marcos Malumbres, Laurie H. Glimcher, Wenyi Wei. The APC/Cdh1 E3 ubiquitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-cycle regulators for destruction. There is mounting evidence indicating that....
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Molecular Cell
Li Chen, Vassilia Balabanidou, David P. Remeta, Conceição A.S.A. Minetti, Athina G. Portaliou, Anastassios Economou, Charalampos G. Kalodimos. Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by finely tuned structural instability an....
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Molecular Cell
Joshua A. Arribere, Jennifer A. Doudna, Wendy V. Gilbert. Cell survival in changing environments requires appropriate regulation of gene expression, including posttranscriptional regulatory mechanisms. From reporter gene studies in glucose-starved yeast,....
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Molecular Cell
Nerea Sanvisens, M. Carmen Bañó, Mingxia Huang, Sergi Puig. Ribonucleotide reductase (RNR) is an essential enzyme required for DNA synthesis and repair. Although iron is necessary for class Ia RNR activity, little is known about the mechanisms that control....
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Molecular Cell
Hiroto Katoh, Zhaohui S. Qin, Runhua Liu, Lizhong Wang, Weiquan Li, Xiangzhi Li, Lipeng Wu, Zhanwen Du, Robert Lyons, Chang-Gong Liu, Xiuping Liu, Yali Dou, Pan Zheng, Yang Liu. Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we ....
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Molecular Cell
Adam M. Schmitt, Clayton D. Crawley, Shijune Kang, David R. Raleigh, Xiaohong Yu, Joshua S. Wahlstrom, David J. Voce, Thomas E. Darga, Ralph R. Weichselbaum, Bakhtiar Yamini. The functional significance of the signaling pathway induced by O6-methylguanine (O6-MeG) lesions is poorly understood. Here, we identify the p50 subunit of NF-κB as a centra....
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17:00
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Molecular Cell
Hyunkyung Kim, Ji Min Lee, Gina Lee, Jinhyuk Bhin, Se Kyu Oh, Kyeongkyu Kim, Ki Eun Pyo, Jason S. Lee, Hwa Young Yim, Keun Il Kim, Daehee Hwang, Jongkyeong Chung, Sung Hee Baek. A critical component of the DNA damage response is the p53 tumor suppressor, and aberrant p53 function leads to uncontrolled cell proliferation and malignancy. Several molecules have been shown to....
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Molecular Cell
Natalia Gebert, Michael Gebert, Silke Oeljeklaus, Karina von der Malsburg, David A. Stroud, Bogusz Kulawiak, Christophe Wirth, René P. Zahedi, Pavel Dolezal, Sebastian Wiese, Oliver Simon, Agnes Schulze-Specking, Kaye N. Truscott, Albert Sickmann, Peter Rehling, Bernard Guiard, Carola Hunte, Bettina Warscheid, Martin van der Laan, Nikolaus Pfanner, Nils Wiedemann. The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further subunit of the carrier translocase (T....
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Molecular Cell
Franck Gallardo, Nancy Laterreur, Emilio Cusanelli, Faissal Ouenzar, Emmanuelle Querido, Raymund J. Wellinger, Pascal Chartrand. The telomerase, which is composed of both protein and RNA, maintains genome stability by replenishing telomeric repeats at the ends of chromosomes. Here, we use live-cell imaging to follow yeast t....
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Molecular Cell
Anna-Carina Jungkamp, Marlon Stoeckius, Desirea Mecenas, Dominic Grün, Guido Mastrobuoni, Stefan Kempa, Nikolaus Rajewsky. Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive ....
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17:00
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Molecular Cell
Sanjeevkumar R. Patel, Samina S. Bhumbra, Raghavendra S. Paknikar, Gregory R. Dressler. The repression of transcription, through the concerted actions of tissue specific DNA binding proteins, Polycomb repressor complexes, and DNA methylation, is essential for maintaining stem cell pl....
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Molecular Cell
George-Lucian Moldovan, Donniphat Dejsuphong, Mark I.R. Petalcorin, Kay Hofmann, Shunichi Takeda, Simon J. Boulton, Alan D. D'Andrea. Inappropriate homologous recombination (HR) causes genomic instability and cancer. In yeast, the UvrD family helicase Srs2 is recruited to sites of DNA replication by SUMO-modified PCNA, where it ....
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17:00
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Molecular Cell
Max R. Banko, Jasmina J. Allen, Bethany E. Schaffer, Erik W. Wilker, Peiling Tsou, Jamie L. White, Judit Villén, Beatrice Wang, Sara R. Kim, Kei Sakamoto, Steven P. Gygi, Lewis C. Cantley, Michael B. Yaffe, Kevan M. Shokat, Anne Brunet. The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use....
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Molecular Cell
Sylvain Egloff, Justyna Zaborowska, Clélia Laitem, Tamás Kiss, Shona Murphy. The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II) comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Reversible phospho....
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Molecular Cell
Sean P. Cullen, Conor M. Henry, Seamus J. Martin. Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhi....
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17:00
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Molecular Cell
Srinivasa M. Srinivasula, Jonathan D. Ashwell. In this issue of Molecular Cell, Skaug et al. (2011) propose a polyubiquitin-dependent, noncatalytic mechanism by which the deubiquitinase A20 inhibits IκB kinase and NF-κB activation.
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Molecular Cell
Teeru Bihani, Philip W. Hinds. In this issue of Molecular Cell, Yang et al. (2011) demonstrate that Aurora B phosphorylates ATM, leading to its mitotic activation and ability to phosphorylate Bub1 and regulate the spindl....
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17:00
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Molecular Cell
Mario Cioce, Giovanni Blandino. In this issue of Molecular Cell, Sen et al. (2011) report the involvement of PGC1α in modulating the transcriptional activity of p53 in metabolically challenged cells. They provide importan....
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Molecular Cell
Hyungsoo Kim, Maria C. Scimia, Deepti Wilkinson, Ramon D. Trelles, Malcolm R. Wood, David Bowtell, Andrew Dillin, Mark Mercola, Ze'ev A. Ronai. Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological conditions. Here we demonstrate that hy....
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Molecular Cell
Dong Hoon Kang, Doo Jae Lee, Kyung Wha Lee, Yoon Sun Park, Joo Young Lee, Sang-Hee Lee, Young Jun Koh, Gou-Young Koh, Chulhee Choi, Dae-Yeul Yu, Jaesang Kim, Sang Won Kang. Cellular antioxidant enzymes play crucial roles in aerobic organisms by eliminating detrimental oxidants and maintaining the intracellular redox homeostasis. Therefore, the function of antioxidant....
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Molecular Cell
Brian Skaug, Jueqi Chen, Fenghe Du, Jin He, Averil Ma, Zhijian J. Chen. A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ ....
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Molecular Cell
Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, Phillip D. Zamore. piRNAs guide PIWI proteins to silence transposons in animal germ cells. Reciprocal cycles of piRNA-directed RNA cleavage—catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) in ....
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Molecular Cell
Thomas Gonatopoulos-Pournatzis, Sianadh Dunn, Rebecca Bounds, Victoria H. Cowling. The 7-methylguanosine cap added to the 5′ end of mRNA is required for efficient gene expression in eukaryotes. In mammals, methylation of the guanosine cap is catalyzed by RNMT (RNA guanine-7 meth....
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Molecular Cell
Chunying Yang, Xi Tang, Xiaojing Guo, Yohei Niikura, Katsumi Kitagawa, Kemi Cui, Stephen T.C. Wong, Li Fu, Bo Xu. The ATM kinase plays a critical role in the maintenance of genetic stability. ATM is activated in response to DNA damage and is essential for cell-cycle checkpoints. Here, we report that ATM is ac....
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Molecular Cell
Alex J. Kuo, Peggie Cheung, Kaifu Chen, Barry M. Zee, Mitomu Kioi, Josh Lauring, Yuanxin Xi, Ben Ho Park, Xiaobing Shi, Benjamin A. Garcia, Wei Li, Or Gozani. The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. Howev....
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Molecular Cell
Nirmalya Sen, Yatendra Kumar Satija, Sanjeev Das. Metabolic stress results in p53 activation, which can trigger cell-cycle arrest, ROS clearance, or apoptosis. However, what determines the p53-mediated cell fate decision upon metabolic stress is ....
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Molecular Cell
Jing Zhou, Kook Sun Ha, Arthur La Porta, Robert Landick, Steven M. Block. Transcriptional pausing by RNA polymerase (RNAP) plays an essential role in gene regulation. Pausing is modified by various elongation factors, including prokaryotic NusA, but the mechanisms under....
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Molecular Cell
Kaori K. Takai, Tatsuya Kibe, Jill R. Donigian, David Frescas, Titia de Lange. To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclu....
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Molecular Cell
Karen Jack, Cristian Bellodi, Dori M. Landry, Rachel O. Niederer, Arturas Meskauskas, Sharmishtha Musalgaonkar, Noam Kopmar, Olya Krasnykh, Alison M. Dean, Sunnie R. Thompson, Davide Ruggero, Jonathan D. Dinman. How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthas....
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Molecular Cell
Folami Y. Ideraabdullah, Marisa S. Bartolomei. In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-spe....
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Molecular Cell
Manel Camps, Brandt F. Eichman. In this issue of Molecular Cell, Dango and Mosammaparast discover that the human oxidative demethylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine ....
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Molecular Cell
Sarah Bajan, Gyorgy Hutvagner. In this issue of Molecular Cell,Suzuki et al. (2011) present the intriguing finding that an RNAse known to play an important role in immunity regulates miRNA processing in cancer and inflam....
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Molecular Cell
Trent Fowler, Ranjan Sen, Ananda L. Roy. Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. T....
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Molecular Cell
Simon Quenneville, Gaetano Verde, Andrea Corsinotti, Adamandia Kapopoulou, Johan Jakobsson, Sandra Offner, Ilaria Baglivo, Paolo V. Pedone, Giovanna Grimaldi, Andrea Riccio, Didier Trono. The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KA....
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